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Fig. S1 pat-4/ILK mRNA levels are reduced in C. elegans by whole-life and adult-only RNAi treatments.

Fig. S2 Effects of reduction of integrin-complex components in C. elegans expressing GFP-tagged PAT-4/ILK.

Fig. S3 Effects on stress-inducible GFP reporters following inhibition of pat-4/ILK in adult C. elegans transcription factor mutants.

Fig. S4 pat-4/ILK mRNA levels are reduced in hsf-1 mutants.

Fig. S5 Reduction of pat-4/ILK in gcy-8 and ttx-3 mutants does not increase transcription of HSF-1 target genes.

Fig. S6 Thermotactic behavior is intact in C. elegans with reduced PAT-4/ILK levels.

Fig. S7 Whole-life inhibition of pat-4/ILK increases aggregation of polyglutamine-expansion repeats in C. elegans.

acel12189-sup-0002-SupportingInformation.docWord document575K

Table S1 Lifespan analysis of various strains subjected to pat-4/ILK RNAi.

Table S2 Survival analysis of wild-type animals subjected to RNAi against components of the integrin complex and cytoskeleton during adulthood and incubated at 36°C.

Table S3 Summary of phenotypes observed in animals subjected to RNAi of integrin complex and cytoskeletal components.

Table S4 Survival analysis of transcription factor mutants subjected to pat-4/ILK RNAi during adulthood and incubated at 36°C.

Table S5 Survival analysis of mutants with defects in neurons involved in thermosensation subjected to pat-4/ILK RNAi during adulthood and incubated at 36°C.

Table S6 Survival analysis of gon-2 mutants subjected to pat-4/ILK RNAi during adulthood and incubated at 36°C.

Table S7 C. elegans strains used in this study.

Table S8 Sequences of quantitative RT-PCR primers used in this study.

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