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Fig. S1 ilk heterozygotes and mys heterozygotes retard cardiac decline with age.

Fig. S2 mRNA levels of ilk and mys do not change with age.

Fig. S3 ilk expression is reduced by cardiac RNAi knockdown.

Fig. S4 pinch, mys, and talin RNAi but not ilk heterozygous mutants induce gaps between cardiomyocytes.

Fig. S5 Heterozygous mutants for parvin, pinch and talin lack age-dependent heart function changes.

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