These three authors contributed equally to this study.
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Article first published online: 9 FEB 2014
© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 3, pages 468–477, June 2014
How to Cite
Miller, R. A., Harrison, D. E., Astle, C. M., Fernandez, E., Flurkey, K., Han, M., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., Pletcher, S., Salmon, A. B., Sharp, Z. D., Van Roekel, S., Winkleman, L. and Strong, R. (2014), Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell, 13: 468–477. doi: 10.1111/acel.12194
- Issue published online: 23 MAY 2014
- Article first published online: 9 FEB 2014
- Accepted manuscript online: 17 DEC 2013 05:54AM EST
- Manuscript Accepted: 7 DEC 2013
- NIH. Grant Numbers: AG022303, AG031736, AG022307, AG13319, AG022308, CA034196
Fig. S1 Survival curves at each of the three test sites.
Fig. S2 Sexual dimorphism in rapamycin blood concentrations.
Fig. S3 Gompertz plots for control and rapamycin-treated (42 ppm) mice.
Fig. S4 Fat mass, as a proportion of total mass, in 9-month-old mice exposed to various doses of rapamycin from 4 months of age.
Table S1 Survival statistics for each test site.
Table S2 Estimation of Gompertz parameters for rapamycin-treated mice.
Table S3 Effects of DR and Rapamycin on expression levels in liver of 52 mRNA for XME genes.
Table S4 Characteristics of the assays used for the work shown in Fig. 3.
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