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Fig. S1 Survival curves at each of the three test sites.

Fig. S2 Sexual dimorphism in rapamycin blood concentrations.

Fig. S3 Gompertz plots for control and rapamycin-treated (42 ppm) mice.

Fig. S4 Fat mass, as a proportion of total mass, in 9-month-old mice exposed to various doses of rapamycin from 4 months of age.

Table S1 Survival statistics for each test site.

Table S2 Estimation of Gompertz parameters for rapamycin-treated mice.

Table S3 Effects of DR and Rapamycin on expression levels in liver of 52 mRNA for XME genes.

Table S4 Characteristics of the assays used for the work shown in Fig. 3.

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