Smurf2 regulates hematopoietic stem cell self-renewal and aging
Article first published online: 4 FEB 2014
© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 3, pages 478–486, June 2014
How to Cite
Ramkumar, C., Kong, Y., Trabucco, S. E., Gerstein, R. M. and Zhang, H. (2014), Smurf2 regulates hematopoietic stem cell self-renewal and aging. Aging Cell, 13: 478–486. doi: 10.1111/acel.12195
- Issue published online: 23 MAY 2014
- Article first published online: 4 FEB 2014
- Manuscript Accepted: 11 DEC 2013
- National Cancer Institute. Grant Number: R01CA131210
- The Ellison Medical Foundation. Grant Number: AG-NS-0347-06
Fig. S1 Smurf2 expression in sorted HSCs, MPPs, CLPs, and body weights of wild-type and Smurf2-deficient mice.
Fig. S2 Average numbers of progenitor populations in bone marrows of wild-type and Smurf2-deficient mice at young and old ages.
Fig. S3 Complete blood count analysis of peripheral blood in wild-type and Smurf2-deficient mice at young and old ages.
Fig. S4 Cell proliferation of bone marrow cells and progenitor populations in wild-type and Smurf2-deficient mice.
Fig. S5 Donor contributions to bone marrow and complete blood count analysis of peripheral blood in recipient mice during serial transplantation.
Fig. S6 Survival of recipient mice receiving bone marrow from 2-month-old Smurf2-deficient donors in the 5th transplantation cycle.
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