• Brandes RP, Fleming I, Busse R (2005) Endothelial aging. Cardiovasc. Res. 66, 286294.
  • Chiasson VL, Quinn MA, Young KJ, Mitchell BM (2011) Protein kinase CbetaII-mediated phosphorylation of endothelial nitric oxide synthase threonine 495 mediates the endothelial dysfunction induced by FK506 (tacrolimus). J. Pharmacol. Exp. Ther. 337, 718723.
  • Freidja ML, Tarhouni K, Toutain B, Fassot C, Loufrani L, Henrion D (2012) The AGE-breaker ALT-711 restores high blood flow-dependent remodeling in mesenteric resistance arteries in a rat model of type 2 diabetes. Diabetes 61, 15621572.
  • Govers R, Rabelink TJ (2001) Cellular regulation of endothelial nitric oxide synthase. Am. J. Physiol. Renal Physiol. 280, F193F206.
  • Hallam KM, Li Q, Ananthakrishnan R, Kalea A, Zou YS, Vedantham S, Schmidt AM, Yan SF, Ramasamy R (2010) Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats. Aging Cell 9, 776784.
  • Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M (2011) Glyoxalase I retards renal senescence. Am. J. Pathol. 179, 28102821.
  • Inagi R, Miyata T, Ueda Y, Yoshino A, Nangaku M, van Ypersele de Strihou C, Kurokawa K (2002) Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid. Kidney Int. 62, 679687.
  • Kakoki M, Hirata Y, Hayakawa H, Suzuki E, Nagata D, Tojo A, Nishimatsu H, Nakanishi N, Hattori Y, Kikuchi K, Nagano T, Omata M (2000) Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure. J. Am. Soc. Nephrol. 11, 301309.
  • Klatt P, Schmidt K, Lehner D, Glatter O, Bachinger HP, Mayer B (1995) Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer. EMBO J. 14, 36873695.
  • Kumagai T, Nangaku M, Kojima I, Nagai R, Ingelfinger JR, Miyata T, Fujita T, Inagi R (2009) Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats. Am. J. Physiol. Renal Physiol. 296, F912F921.
  • Lakatta EG, Levy D (2003) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a “set up” for vascular disease. Circulation 107, 139146.
  • Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sorlie P, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J (2010) Heart disease and stroke statistics–2010 update: a report from the American Heart Association. Circulation 121, e46e215.
  • Seals DR, Jablonski KL, Donato AJ (2011) Aging and vascular endothelial function in humans. Clin. Sci. (Lond) 120, 357375.
  • Sena CM, Matafome P, Crisostomo J, Rodrigues L, Fernandes R, Pereira P, Seica RM (2012) Methylglyoxal promotes oxidative stress and endothelial dysfunction. Pharmacol. Res. 65, 497506.
  • Thornalley PJ (1993) The glyoxalase system in health and disease. Mol. Aspects Med. 14, 287371.
  • Thornalley PJ (2003) Glyoxalase I–structure, function and a critical role in the enzymatic defence against glycation. Biochem. Soc. Trans. 31, 13431348.
  • Thornalley PJ (2008) Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems – role in ageing and disease. Drug Metabol. Drug Interact. 23, 125150.
  • Wautier JL, Schmidt AM (2004) Protein glycation: a firm link to endothelial cell dysfunction. Cardiovasc. Res. 95, 233238.
  • Xie L, Liu Z, Lu H, Zhang W, Mi Q, Li X, Tang Y, Chen Q, Ferro A, Ji Y (2012) Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCα signalling pathway in human umbilical vein endothelial cells. Br. J. Pharmacol. 165, 754764.