SEARCH

SEARCH BY CITATION

References

  • Barzilai N, Gabriely I, Gabriely M, Iankowitz N, Sorkin JD (2001) Offspring of centenarians have a favorable lipid profile. J. Am. Geriatr. Soc. 49, 7679.
  • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate – a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B Methodol. 57, 289300.
  • Bo TH, Dysvik B, Jonassen I (2004) LSimpute: accurate estimation of missing values in microarray data with least squares methods. Nucleic Acids Res. 32, e34.
  • Burger JM, Promislow DEL (2004) Sex-specific effects of interventions that extend fly life span. Sci. Aging Knowledge Environ. 2004, pe30.
  • Caspi R, Altman T, Dreher K, Fulcher CA, Subhraveti P, Keseler IM, Kothari A, Krummenacker M, Latendresse M, Mueller LA, Ong Q, Paley S, Pujar A, Shearer AG, Travers M, Weerasinghe D, Zhang P, Karp PD (2012) The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res. 40, D742D753.
  • Chintapalli VR, Al Bratty M, Korzekwa D, Watson DG, Dow JA (2013) Mapping an atlas of tissue-specific Drosophila melanogaster metabolomes by high resolution mass spectrometry. PLoS ONE 8, e78066.
  • Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D (2013) Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol. 11, e1001613.
  • Corby-Harris V, Pontaroli AC, Shimkets LJ, Bennetzen JL, Habel KE, Promislow DEL (2007) Geographical distribution and diversity of bacteria associated with natural populations of Drosophila melanogaster. Appl. Environ. Microbiol. 73, 34703479.
  • De Guzman JM, Ku G, Fahey R, Youm YH, Kass I, Dixit VD, Kheterpal I (2012) Chronic caloric restriction partially protects against age-related alteration in serum metabolome. Age 35, 10911104.
  • De Luca M, Roshina NV, Geiger-Thornsberry GL, Lyman RF, Pasyukova EG, Mackay TF (2003) Dopa decarboxylase (Ddc) affects variation in Drosophila longevity. Nat. Genet. 34, 429433.
  • Fuchs S, Bundy JG, Davies SK, Viney JM, Swire JS, Leroi AM (2010) A metabolic signature of long life in Caenorhabditis elegans. BMC Biol. 8, 14.
  • Gomez LA, Heath SH, Hagen TM (2012) Acetyl-l-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the l-carnitine content in the rat heart. Mech. Ageing Dev. 133, 99106.
  • Grandison RC, Piper MD, Partridge L (2009) Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462, 10611064.
  • Hoffmann A, Parsons P (1988) The analysis of quantitative variation in natural populations with isofemale strains. Genet. Sel. Evol. 20, 8798.
  • Houtkooper RH, Argmann C, Houten SM, Canto C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J (2011) The metabolic footprint of aging in mice. Sci. Rep. 1, 134.
  • Jeck WR, Siebold AP, Sharpless NE (2012) Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell 11, 727731.
  • Jewison T, Knox C, Neveu V, Djoumbou Y, Guo AC, Lee J, Liu P, Mandal R, Krishnamurthy R, Sinelnikov I, Wilson M, Wishart DS (2012) YMDB: the yeast metabolome database. Nucleic Acids Res. 40, D815D820.
  • Jones DP, Park Y, Ziegler TR (2012) Nutritional metabolomics: progress in addressing complexity in diet and health. Annu. Rev. Nutr. 32, 183202.
  • Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikainen LP, Kangas AJ, Soininen P, Wurtz P, Silander K, Dick DM, Rose RJ, Savolainen MJ, Viikari J, Kahonen M, Lehtimaki T, Pietilainen KH, Inouye M, McCarthy MI, Jula A, Eriksson J, Raitakari OT, Salomaa V, Kaprio J, Jarvelin MR, Peltonen L, Perola M, Freimer NB, Ala-Korpela M, Palotie A, Ripatti S (2012) Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat. Genet. 44, 269276.
  • Kirkwood TB, Feder M, Finch CE, Franceschi C, Globerson A, Klingenberg CP, LaMarco K, Omholt S, Westendorp RG (2005) What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech. Ageing Dev. 126, 439443.
  • Kostal V, Korbelova J, Rozsypal J, Zahradnickova H, Cimlova J, Tomcala A, Simek P (2011) Long-term cold acclimation extends survival time at 0 degrees C and modifies the metabolomic profiles of the larvae of the fruit fly Drosophila melanogaster. PLoS ONE 6, e25025.
  • Li S, Park Y, Duraisingham S, Strobel FH, Khan N, Soltow QA, Jones DP, Pulendran B (2013) Predicting network activity from high throughput metabolomics. PLoS Comput. Biol. 9, e1003123.
  • Mackay TF, Richards S, Stone EA, Barbadilla A, Ayroles JF, Zhu D, Casillas S, Han Y, Magwire MM, Cridland JM, Richardson MF, Anholt RR, Barron M, Bess C, Blankenburg KP, Carbone MA, Castellano D, Chaboub L, Duncan L, Harris Z, Javaid M, Jayaseelan JC, Jhangiani SN, Jordan KW, Lara F, Lawrence F, Lee SL, Librado P, Linheiro RS, Lyman RF, Mackey AJ, Munidasa M, Muzny DM, Nazareth L, Newsham I, Perales L, Pu LL, Qu C, Ramia M, Reid JG, Rollmann SM, Rozas J, Saada N, Turlapati L, Worley KC, Wu YQ, Yamamoto A, Zhu Y, Bergman CM, Thornton KR, Mittelman D, Gibbs RA (2012) The Drosophila melanogaster genetic reference panel. Nature 482, 173178.
  • Mishur RJ, Rea SL (2012) Applications of mass spectrometry to metabolomics and metabonomics: Detection of biomarkers of aging and of age-related diseases. Mass Spectrom. Rev. 31, 7095.
  • Moghadam NN, Holmstrup M, Pertoldi C, Loeschcke V (2013) Age-induced perturbation in cell membrane phospholipid fatty acid profile of longevity-selected Drosophila melanogaster and corresponding control lines. Exp. Gerontol. 48, 13621368.
  • Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens RD, Hegardt FG, Muoio DM (2009) Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J. Biol. Chem. 284, 2284022852.
  • Overgaard J, Tomcala A, Sorensen JG, Holmstrup M, Krogh PH, Simek P, Kostal V (2008) Effects of acclimation temperature on thermal tolerance and membrane phospholipid composition in the fruit fly Drosophila melanogaster. J. Insect Physiol. 54, 619629.
  • Oxenkrug GF, Navrotskaya V, Voroboyva L, Summergrad P (2011) Extension of life span of Drosophila melanogaster by the inhibitors of tryptophan-kynurenine metabolism. Fly 5, 307309.
  • Parisi M, Li R, Oliver B (2011) Lipid profiles of female and male Drosophila. BMC Res Notes. 4, 198.
  • Park JH, Wacholder S, Gail MH, Peters U, Jacobs KB, Chanock SJ, Chatterjee N (2010) Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat. Genet. 42, 570575.
  • Pletcher SD, Macdonald SJ, Marguerie R, Certa U, Stearns SC, Goldstein DB, Partridge L (2002) Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr. Biol. 12, 712723.
  • Psihogios NG, Gazi IF, Elisaf MS, Seferiadis KI, Bairaktari ET (2008) Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics. NMR Biomed. 21, 195207.
  • R Core Team (2013) R: A language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.
  • Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE (2013) A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab. 18, 130143.
  • Sarup P, Pedersen SM, Nielsen NC, Malmendal A, Loeschcke V (2012) The metabolic profile of long-lived Drosophila melanogaster. PLoS ONE 7, e47461.
  • Scheitz CJ, Guo Y, Early AM, Harshman LG, Clark AG (2013) Heritability and inter-population differences in lipid profiles of Drosophila melanogaster. PLoS ONE 8, e72726.
  • Slupsky CM, Rankin KN, Wagner J, Fu H, Chang D, Weljie AM, Saude EJ, Lix B, Adamko DJ, Shah S, Greiner R, Sykes BD, Marrie TJ (2007) Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. Anal. Chem. 79, 69957004.
  • Soltow QA, Jones DP, Promislow DEL (2010) A network perspective on metabolism and aging. Integr. Comp. Biol. 50, 844854.
  • Soltow QA, Strobel FH, Mansfield KG, Wachtman L, Park Y, Jones DP (2011) High-performance metabolic profiling with dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) for study of the exposome. Metabolomics 9, 132143.
  • Suhre K, Gieger C (2012) Genetic variation in metabolic phenotypes: study designs and applications. Nat. Rev. Genet. 13, 759769.
  • Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wagele B, Altmaier E, CardioGram Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmuller G, Kottgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Romisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C (2011) Human metabolic individuality in biomedical and pharmaceutical research. Nature 477, 5460.
  • Toivonen JM, Gems D, Partridge L (2009) Longevity of Indy mutant Drosophila not attributable to Indy mutation. Proc. Natl Acad. Sci. USA 106, E53; author reply E54.
  • Uppal K, Soltow QA, Strobel FH, Pittard WS, Gernert KM, Yu T, Jones DP (2013) xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data. BMC Bioinformatics 14, Article 15.
  • Vermeulen CJ, Cremers TI, Westerink BH, Van De Zande L, Bijlsma R (2006) Changes in dopamine levels and locomotor activity in response to selection on virgin lifespan in Drosophila melanogaster. Mech. Ageing Dev. 127, 610617.
  • Westerhuis JA, Hoefsloot HCJ, Smit S, Vis DJ, Smilde AK, van Velzen EJJ, van Duijnhoven JPM, van Dorsten FA (2008) Assessment of PLSDA cross validation. Metabolomics 4, 8189.
  • Wijeyesekera A, Selman C, Barton RH, Holmes E, Nicholson JK, Withers DJ (2012) Metabotyping of long-lived mice using 1H NMR spectroscopy. J. Proteome Res. 11, 22242235.
  • Yu T, Park Y, Johnson JM, Jones DP (2009) apLCMS-adaptive processing of high resolution LC/MS data. Bioinformatics 25, 19301936.
  • Yu Z, Zhai G, Singmann P, He Y, Xu T, Prehn C, Romisch-Margl W, Lattka E, Gieger C, Soranzo N, Heinrich J, Standl M, Thiering E, Mittelstrass K, Wichmann HE, Peters A, Suhre K, Li Y, Adamski J, Spector TD, Illig T, Wang-Sattler R (2012) Human serum metabolic profiles are age dependent. Aging Cell 11, 960967.