Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster
Version of Record online: 18 MAR 2014
© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 4, pages 596–604, August 2014
How to Cite
Hoffman, J. M., Soltow, Q. A., Li, S., Sidik, A., Jones, D. P. and Promislow, D. E. L. (2014), Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster. Aging Cell, 13: 596–604. doi: 10.1111/acel.12215
- Issue online: 29 JUL 2014
- Version of Record online: 18 MAR 2014
- Manuscript Accepted: 25 JAN 2014
- NIH. Grant Numbers: T32 GM007103, R01AG038756
- NSF. Grant Number: 1021720
- AFAR/EMF Breakthroughs In Gerontology grant
|acel12215-sup-0001-FigS1.pdf||PDF document||450K||Fig. S1 Histogram of intraclass correlations among all metabolites for AE (top) and C18 (bottom) columns.|
|acel12215-sup-0002-FigS2.pdf||PDF document||513K||Fig. S2 Sparse partial least squares discriminant analysis is able to distinguish samples of different age, where age is treated as a factor rather than a continuous variable as in Fig. 4, with relatively high accuracy.|
|acel12215-sup-0003-FigS3.pdf||PDF document||532K||Fig. S3 Carnitine shuttle pathway from mummichog analysis of metabolites, with color and intensity determined by the sign and magnitude of the regression coefficient in the age model (blue is negative, red is positive).|
|acel12215-sup-0004-TableS1.xlsx||application/msexcel||9K||Table S1 Bloomington Stock Center numbers, DGRP numbers, and wolbachia status for those inbred lines analyzed in this study.|
|acel12215-sup-0005-TableS2.xlsx||application/msexcel||13K||Table S2 Mummichog enrichment analysis for sets of analytes significantly associated with specific factors.|
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