Maternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspring
Version of Record online: 24 MAR 2014
© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 4, pages 623–630, August 2014
How to Cite
Gribble, K. E., Jarvis, G., Bock, M. and Mark Welch, D. B. (2014), Maternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspring. Aging Cell, 13: 623–630. doi: 10.1111/acel.12217
- Issue online: 29 JUL 2014
- Version of Record online: 24 MAR 2014
- Manuscript Accepted: 17 FEB 2014
- National Institute on Aging Division of Aging Biology. Grant Number: R01 AG037960-01
- Ellison Medical Foundation/American Federation
- Aging Research Postdoctoral Fellows in Aging Research Program
- Neil Cornell Career Development Award
- caloric restriction;
- maternal effect;
- monogonont rotifer
While many studies have focused on the detrimental effects of advanced maternal age and harmful prenatal environments on progeny, little is known about the role of beneficial non-Mendelian maternal inheritance on aging. Here, we report the effects of maternal age and maternal caloric restriction (CR) on the life span and health span of offspring for a clonal culture of the monogonont rotifer Brachionus manjavacas. Mothers on regimens of chronic CR (CCR) or intermittent fasting (IF) had increased life span compared with mothers fed ad libitum (AL). With increasing maternal age, life span and fecundity of female offspring of AL-fed mothers decreased significantly and life span of male offspring was unchanged, whereas body size of both male and female offspring increased. Maternal CR partially rescued these effects, increasing the mean life span of AL-fed female offspring but not male offspring and increasing the fecundity of AL-fed female offspring compared with offspring of mothers of the same age. Both maternal CR regimens decreased male offspring body size, but only maternal IF decreased body size of female offspring, whereas maternal CCR caused a slight increase. Understanding the genetic and biochemical basis of these different maternal effects on aging may guide effective interventions to improve health span and life span.