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Fig. S1 The networks with the highest network's score of different types of miRNAs: (A) nondifferentially expressed; (B) expressed in both groups, but down-regulated in adults; (C) expressed in both groups, but up-regulated in adults; and (D) decreased expression from young to middle-aged adulthood. The figure was drawn using IPA software.

Fig. S2 The scatter plot of miRNA expression levels on age in the adults (n = 60) of the screening set, with a fitted linear regression line displayed in solid line.

Fig. S3 The scatter plot of miRNA expression levels on age in the adults (n = 68) of the validation set, with a fitted linear regression line displayed in solid line.

Table S1 Demographic characteristics of the participants in the screening set and the validation set, respectively.

Table S2 The class of miRNAs with age-constant expression: the microRNAs (n = 104) that were nondifferentially expressed between preterm-infants (n = 30) and adults (n = 60), and their chromosomal locations.

Table S3 The class of miRNAs with age-limited expression: the miRNAs (n = 23) that were expressed either in preterm-infants only or in adults only, and their chromosomal locations.

Table S4 The class of miRNAs with age-related modulation-down regulated in adults: the miRNAs (n = 20) that were differentially expressed between preterm-infants (n = 30) and adults (n = 60), down-regulated in adults, and their chromosomal locations.

Table S5 The class of miRNAs with age-related modulation-up regulated in adults: the miRNAs (n = 81) that were differentially expressed between preterm-infants (n = 30) and adults (n = 60), up-regulated in adults, and their chromosomal locations.

Table S6 Distribution of chromosomal locations for detectable miRNAs.

Table S7 The detailed chromosomal loci of miRNAs located in four chromosomes that showed a higher proportion for a certain class of miRNAs than the averaged ones as shown in Table S6.

Table S8 Top five associated canonical pathways for predicted miR-target genes of the miRNA that were clustered on 14q32.31 and 9q22.

Table S9 The target genes derived from the top five associated canonical pathways for the age-constant expression miRNAs clustered on 14q32.31.

Table S10 The target genes derived from the top five associated canonical pathways for the age-related up-regulation expression in adults miRNAs clustered on 9q22.32.

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