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acel12247-sup-0001-FigS1.tifimage/tif2917KFig. S1 SIRT1, PAI-1, and p21 protein expressions in 30 AS plaques.
acel12247-sup-0002-FigS2.tifimage/tif3499KFig. S2 SA-β-gal staining (A) and Hoechest staining (B) on young and senescent HUVECs.
acel12247-sup-0003-FigS3.tifimage/tif178KFig. S3 Analysis of p16 expression in HUVECs (A) and assay of plasma PAI-1 level of mice (B).
acel12247-sup-0004-FigS4.tifimage/tif683KFig. S4 PAI-1 expression in 293A treated with sirtuin inhibitors and in HUVECs treated with drugs as indicated.
acel12247-sup-0005-FigS5.tifimage/tif188KFig. S5 P53 and p21 mRNA and protein expression in the aortas of old WT and SIRT1-Tg mice.
acel12247-sup-0006-FigS6.tifimage/tif184KFig. S6 SIRT1 and PAI-1 protein expressions in the aortas of old SIRT1(+/+) and SIRT1(+/-) mice.
acel12247-sup-0007-FigS7.tifimage/tif182KFig. S7 The PAI-1 promoter activity affected by SIRT1 overexpression or SIRT1 inhibitor using the dual-luciferase reporter assay.
acel12247-sup-0008-FigS8.tifimage/tif104KFig. S8 H3K9Ac level on the PAI-1 promoter by ChIP assays performed with chromatin prepared from young and senescent HUVECs.
acel12247-sup-0009-FigS9.tifimage/tif261KFig. S9 Pol II level on the PAI-1 promoter by ChIP assays performed with chromatin prepared from young and senescent HUVECs.
acel12247-sup-0010-TableS1.docWord document79KTable S1 Primer sequences used in the article.

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