Both authors contributed equally to this work.
PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation
Article first published online: 18 JUL 2014
© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 5, pages 879–889, October 2014
How to Cite
Jin, B., Wang, Y., Wu, C. L., Liu, K. Y., Chen, H. and Mao, Z. B. (2014), PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. Aging Cell, 13: 879–889. doi: 10.1111/acel.12249
- Issue published online: 19 SEP 2014
- Article first published online: 18 JUL 2014
- Manuscript Accepted: 15 JUN 2014
- National Basic Research Programs of China. Grant Numbers: 2013CB530801, 2011CB966203
- Natural Science Foundation of China. Grant Number: 81170318
Method S1 Plasmid and retroviruses.
Table S1 Oligonucleotides used in this study.
Fig. S1 PIM-1 Expression is Up-regulated in senescent WI38 cells.
Fig. S2 Ectopic Expression of PIM-1 Causes Premature Senescence.
Fig. S3 PIM-1 depletion delays cellular senescence in BJ cells.
Fig. S4 PIM-1 knockdown diminishes the DNA-Damage Response of cells to RasV12.
Fig. S5 Anti-pHP1γS93 antibody reacts in western blot analysis with the WT HP1γ protein but not with the S93A mutant, when exposed to rPIM-1 (top panel).
Fig. S6 PKA activity in young and Ras-induced senescent cells.
Fig. S7 Phosphorylated HP1γ that is associated with cellular senescence.
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