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Fig. S1 Generation of the MGS KO mouse.

Fig.S2 MGS and laforin proteins accumulated with polyglucosan bodies (PGBs) in the hippocampus of aged WT and malin KO mice.

Fig. S3 MGS and laforin proteins accumulated with polyglucosan bodies (PGBs) in the cerebellum of aged WT and malin KO mice.

Fig. S4 MGS and laforin proteins accumulated with polyglucosan bodies (PGBs) in the piriform cortex of aged WT and malin KO mice.

Fig. S5 Ubiquitin and 70 kDa heat-shock protein (HSP70) accumulated with polyglucosan bodies (PGBs) in aged WT and malin KO mice.

Fig. S6 Parvalbumin (PV) and alpha-synuclein accumulated with polyglucosan bodies (PGBs) in aged WT and malin KO mice.

Fig. S7 Glycogen accumulation in aged Drosophila as compared to mouse liver glycogen.

Fig. S8 Modulation of neuronal dGS levels detected in whole fly heads using anti-human MGS antibody.

Fig. S9 Identification of neuronal glycogen and glycogen clusters in aged w1118 strain flies.

Fig. S10 Data supporting neuronal RNAi knockdown of dGS and its functional consequences.

Table S1 Descriptive statistics for Drosophila lifespans

acel12254-sup-0002-MovieM1.avivideo/avi2364KMovie S1 Climbing of elav-Gal4 > GFP young flies.
acel12254-sup-0003-MovieM2.avivideo/avi2054KMovie S2 Climbing of elav-Gal4 > dGS-RNAi-NIII young flies.
acel12254-sup-0004-MovieM3.avivideo/avi1885KMovie S3 Climbing of elav-Gal4 > GFP aged flies.
acel12254-sup-0005-MovieM4.avivideo/avi1311KMovie S4 Climbing of elav-Gal4 > dGS-RNAi-NIII aged flies.

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