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Aging Cell

Cover image for Vol. 13 Issue 3

June 2014

Volume 13, Issue 3

Pages i–iii, 391–578

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Review
    4. Original Articles
    5. Short Takes
    1. You have full text access to this Open Access content
      Issue Information (pages i–iii)

      Article first published online: 23 MAY 2014 | DOI: 10.1111/acel.12233

  2. Review

    1. Top of page
    2. Issue Information
    3. Review
    4. Original Articles
    5. Short Takes
    1. You have full text access to this OnlineOpen article
  3. Original Articles

    1. Top of page
    2. Issue Information
    3. Review
    4. Original Articles
    5. Short Takes
    1. You have full text access to this OnlineOpen article
      The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific (pages 401–407)

      Nicola Raule, Federica Sevini, Shengting Li, Annalaura Barbieri, Federica Tallaro, Laura Lomartire, Dario Vianello, Alberto Montesanto, Jukka S. Moilanen, Vladyslav Bezrukov, Hélène Blanché, Antti Hervonen, Kaare Christensen, Luca Deiana, Efstathios S. Gonos, Tom B. L. Kirkwood, Peter Kristensen, Alberta Leon, Pier Giuseppe Pelicci, Michel Poulain, Irene M. Rea, Josè Remacle, Jean Marie Robine, Stefan Schreiber, Ewa Sikora, Peternella Eline Slagboom, Liana Spazzafumo, Maria Antonietta Stazi, Olivier Toussaint, James W. Vaupel, Giuseppina Rose, Kari Majamaa, Markus Perola, Thomas E. Johnson, Lars Bolund, Huanming Yang, Giuseppe Passarino and Claudio Franceschi

      Article first published online: 17 DEC 2013 | DOI: 10.1111/acel.12186

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      Reductions in serum IGF-1 during aging impair health span (pages 408–418)

      Zhenwei Gong, Oran Kennedy, Hui Sun, YingJie Wu, Garry A Williams, Laura Klein, Luis Cardoso, Ronald W. Matheny Jr, Gene B. Hubbard, Yuji Ikeno, Roger P. Farrar, Mitchell B Schaffler, Martin L Adamo, Radhika H Muzumdar and Shoshana Yakar

      Article first published online: 30 DEC 2013 | DOI: 10.1111/acel.12188

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      Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1 (pages 419–430)

      Caroline Kumsta, Tsui-Ting Ching, Mayuko Nishimura, Andrew E. Davis, Sara Gelino, Hannah H. Catan, Xiaokun Yu, Chu-Chiao Chu, Binnan Ong, Siler H. Panowski, Nathan Baird, Rolf Bodmer, Ao-Lin Hsu and Malene Hansen

      Article first published online: 9 JAN 2014 | DOI: 10.1111/acel.12189

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      A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging (pages 431–440)

      Mayuko Nishimura, Caroline Kumsta, Gaurav Kaushik, Soda B. Diop, Yun Ding, Jumana Bisharat-Kernizan, Hannah Catan, Anthony Cammarato, Robert S. Ross, Adam J. Engler, Rolf Bodmer, Malene Hansen and Karen Ocorr

      Article first published online: 9 JAN 2014 | DOI: 10.1111/acel.12193

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      Aging is associated with increased regulatory T-cell function (pages 441–448)

      Sanjay K. Garg, Colin Delaney, Tomomi Toubai, Amiya Ghosh, Pavan Reddy, Ruma Banerjee and Raymond Yung

      Article first published online: 25 FEB 2014 | DOI: 10.1111/acel.12191

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      Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity (pages 457–467)

      Jia Hu, Min Wei, Hamed Mirzaei, Federica Madia, Mario Mirisola, Camille Amparo, Shawna Chagoury, Brian Kennedy and Valter D. Longo

      Article first published online: 20 MAR 2014 | DOI: 10.1111/acel.12202

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      Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction (pages 468–477)

      Richard A. Miller, David E. Harrison, Clinton M. Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A. Javors, Xinna Li, Nancy L. Nadon, James F. Nelson, Scott Pletcher, Adam B. Salmon, Zelton Dave Sharp, Sabrina Van Roekel, Lynn Winkleman and Randy Strong

      Article first published online: 9 FEB 2014 | DOI: 10.1111/acel.12194

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      Smurf2 regulates hematopoietic stem cell self-renewal and aging (pages 478–486)

      Charusheila Ramkumar, Yahui Kong, Sally E. Trabucco, Rachel M. Gerstein and Hong Zhang

      Article first published online: 4 FEB 2014 | DOI: 10.1111/acel.12195

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      Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis (pages 487–496)

      Jelena Vjetrovic, Pattabhiraman Shankaranarayanan, Marco A. Mendoza-Parra and Hinrich Gronemeyer

      Article first published online: 4 MAR 2014 | DOI: 10.1111/acel.12197

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      The contribution of visceral fat to improved insulin signaling in Ames dwarf mice (pages 497–506)

      Vinal Menon, Xu Zhi, Tanvir Hossain, Andrzej Bartke, Adam Spong, Adam Gesing and Michal M. Masternak

      Article first published online: 12 FEB 2014 | DOI: 10.1111/acel.12201

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    13. You have full text access to this OnlineOpen article
      Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation (pages 519–528)

      Airi Jo-Watanabe, Takamoto Ohse, Hiroaki Nishimatsu, Masao Takahashi, Yoichiro Ikeda, Takehiko Wada, Jun-ichi Shirakawa, Ryoji Nagai, Toshio Miyata, Tetsuo Nagano, Yasunobu Hirata, Reiko Inagi and Masaomi Nangaku

      Article first published online: 24 FEB 2014 | DOI: 10.1111/acel.12204

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      Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart (pages 529–539)

      Dao-Fu Dai, Pabalu P. Karunadharma, Ying A. Chiao, Nathan Basisty, David Crispin, Edward J. Hsieh, Tony Chen, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Richard P. Beyer, Michael J. MacCoss and Peter S. Rabinovitch

      Article first published online: 25 FEB 2014 | DOI: 10.1111/acel.12203

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      Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity (pages 551–560)

      Alexia Gómez, Ines Sánchez-Roman, Jose Gomez, Julia Cruces, Ianire Mate, Mónica Lopez-Torres, Alba Naudi, Manuel Portero-Otin, Reinald Pamplona, Monica De la Fuente and Gustavo Barja

      Article first published online: 26 FEB 2014 | DOI: 10.1111/acel.12205

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      Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine (pages 561–572)

      Paola Gamba, Michela Guglielmotto, Gabriella Testa, Debora Monteleone, Chiara Zerbinati, Simona Gargiulo, Fiorella Biasi, Luigi Iuliano, Giorgio Giaccone, Alessandro Mauro, Giuseppe Poli, Elena Tamagno and Gabriella Leonarduzzi

      Article first published online: 25 FEB 2014 | DOI: 10.1111/acel.12206

  4. Short Takes

    1. Top of page
    2. Issue Information
    3. Review
    4. Original Articles
    5. Short Takes
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
      Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness (pages 576–578)

      Bradley S. Fleenor, Jason S. Eng, Amy L. Sindler, Bryant T. Pham, Jackson D. Kloor and Douglas R. Seals

      Article first published online: 21 JAN 2014 | DOI: 10.1111/acel.12196

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