Acute Ethanol Reduces Reversal Cost in Discrimination Learning by Reducing Perseverance in Adolescent Rhesus Macaques
Article first published online: 8 JAN 2013
Copyright © 2013 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 37, Issue 6, pages 952–960, June 2013
How to Cite
Wright Jr, M. J., Glavis-Bloom, C. and Taffe, M. A. (2013), Acute Ethanol Reduces Reversal Cost in Discrimination Learning by Reducing Perseverance in Adolescent Rhesus Macaques. Alcoholism: Clinical and Experimental Research, 37: 952–960. doi: 10.1111/acer.12050
- Issue published online: 28 MAY 2013
- Article first published online: 8 JAN 2013
- Manuscript Accepted: 9 OCT 2012
- Manuscript Received: 2 JUL 2012
- USPHS. Grant Numbers: AA016807, AA007456
- Reversal Learning;
Acute alcohol exposure produces cognitive deficits in adults but less is known about the acute cognitive effects of alcohol in adolescents. The cognitive impact of acute alcohol exposure includes deficits in discrimination and reversal learning, but traditional experimental approaches make it difficult to distinguish the effect of alcohol on discrimination learning from the effect of alcohol on reversal learning. Young rhesus macaques can be used to model some aspects of human adolescence because of their anatomical, neurophysiological, and cognitive similarities with humans.
Adolescent male rhesus monkeys (n = 10) were trained to respond to visual stimuli on touch-sensitive LCD panels controlled by the nonhuman primate version of CANTAB software. Discrimination and reversal learning tasks were subsequently assessed after monkeys were allowed to consume varying amounts of ethanol (EtOH) in a flavored vehicle (vehicle only, up to 0.5 g/kg EtOH, up to 1.0 g/kg EtOH, and up to 1.5 g/kg EtOH).
Acute exposure to EtOH reduced perseverance, increased response accuracy, and reduced errors during reversal learning when the task was completed within 90 minutes of EtOH consumption. No reduction in reversal errors was observed when EtOH was consumed 3 or 24 hours prior to reversal learning. EtOH only impaired discrimination learning when monkeys had very little previous EtOH exposure.
The temporal relationship between EtOH consumption and reversal learning was consistent with selective EtOH-induced impairment of retrieval, but not storage, processes. This was evidenced by diminished perseverance on the previously correct stimulus leading to decreased errors to criterion.