Mice Bred for Severity of Acute Alcohol Withdrawal Respond Differently in a Go/No-Go Task
Article first published online: 11 APR 2013
Copyright © 2013 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 37, Issue 9, pages 1483–1490, September 2013
How to Cite
Moschak, T. M., Stang, K. A. and Mitchell, S. H. (2013), Mice Bred for Severity of Acute Alcohol Withdrawal Respond Differently in a Go/No-Go Task. Alcoholism: Clinical and Experimental Research, 37: 1483–1490. doi: 10.1111/acer.12134
- Issue published online: 29 AUG 2013
- Article first published online: 11 APR 2013
- Manuscript Accepted: 31 JAN 2013
- Manuscript Received: 24 OCT 2012
- Behavioral Inhibition;
- Selected Lines;
Mice selectively bred for high or low withdrawal to acute alcohol differ on a number of traits, including consumption of alcohol, conditioned place preference for alcohol, and sensitivity to alcohol-induced locomotor activity. One trait that has not been examined in these mice is behavioral inhibition.
High and low alcohol withdrawal mice (second replicate: high and low acute alcohol withdrawal [HAW-2/LAW-2]) were trained and tested in a Go/No-go task. Mice were administered 0.0, 0.5, 1.0, and 1.5 g/kg ethanol (EtOH) on 3 occasions according to an incomplete Latin Square. A separate cohort of C57BL/6J (B6) and DBA/2J (D2) mice (the progenitor strains for HAW-2/LAW-2 mice) underwent the same protocol, using the same EtOH doses.
HAW-2 and LAW-2 mice did not differ in behavioral inhibition at baseline, although LAW-2 mice did have higher overall levels of responding in the task. EtOH did not alter behavioral inhibition in these mice. However, it did decrease responses to the Go cue, and this effect was greater in HAW-2 mice than in LAW-2 mice. D2 mice had lower behavioral inhibition than B6 mice at baseline, and EtOH slightly decreased behavioral inhibition in both strains.
The findings with D2 and B6 mice generally fit with the existing literature. However, the lack of a difference in behavioral inhibition between HAW-2 and LAW-2 mice was unexpected, as well as the absence of any effect of these doses of EtOH on behavioral inhibition in these mice. Nonetheless, the findings do suggest that selectively breeding for high or low withdrawal to acute alcohol can lead to differences in operant behavior in the Go/No-go task.