Initial Evidence that OPRM1 Genotype Moderates Ventral and Dorsal Striatum Functional Connectivity During Alcohol Cues
Article first published online: 22 JUL 2013
Copyright © 2013 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 38, Issue 1, pages 78–89, January 2014
How to Cite
Ray, L. A., Courtney, K. E., Hutchison, K. E., MacKillop, J., Galvan, A. and Ghahremani, D. G. (2014), Initial Evidence that OPRM1 Genotype Moderates Ventral and Dorsal Striatum Functional Connectivity During Alcohol Cues. Alcoholism: Clinical and Experimental Research, 38: 78–89. doi: 10.1111/acer.12136
- Issue published online: 21 JAN 2014
- Article first published online: 22 JUL 2013
- Manuscript Accepted: 11 MAR 2013
- Manuscript Received: 12 JUN 2012
- NIAAA. Grant Number: 1R03-AA019569
- Functional Magnetic Resonance Imaging;
- Cue Reactivity;
- Functional Connectivity;
- Dorsal Striatum;
- Ventral Striatum
Endogenous opioids and striatal dopamine have been implicated in cue-induced alcohol craving and have been hypothesized to play a role in goal-directed, as opposed to habitual, alcohol use. This initial study examines dorsal and ventral striatal functional connectivity during alcohol-cue processing as a function of the A118G single-nucleotide polymorphism of the mu-opioid receptor (OPRM1) gene.
Seventeen individuals with alcohol dependence (6 females; 90% Caucasian; mean age = 29.4) underwent blood oxygen level-dependent functional magnetic resonance imaging, while performing an alcohol taste-cues task. Psychophysiological interaction analyses investigated associations of the OPRM1 genotype with ventral and dorsal striatum functional connectivity, using the ventral striatum and the caudate as the seed region, respectively.
Compared to A-allele homozygotes, G-allele carriers of the OPRM1 gene showed (i) greater activation of the insula and orbitofrontal cortex and (ii) stronger negative fronto-striatal functional connectivity for both ventral and dorsal striatal seed regions during processing of alcohol versus water cues.
These preliminary findings suggest that, relative to A-allele homozygotes, G-allele carriers show unstable frontal regulation over reward and/or habit-driven inputs from the striatum resulting from greater reward sensitivity combined with limited self-control resources.