Alpha-Lipoic Acid Reduces Ethanol Self-Administration in Rats
Article first published online: 26 JUN 2013
Copyright © 2013 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 37, Issue 11, pages 1816–1822, November 2013
How to Cite
Peana, A. T., Muggironi, G., Fois, G. and Diana, M. (2013), Alpha-Lipoic Acid Reduces Ethanol Self-Administration in Rats. Alcoholism: Clinical and Experimental Research, 37: 1816–1822. doi: 10.1111/acer.12169
- Issue published online: 24 OCT 2013
- Article first published online: 26 JUN 2013
- Manuscript Accepted: 17 MAR 2013
- Manuscript Received: 29 OCT 2012
- Fondazione Banco di Sardegna. Grant Numbers: 1526/2010.0150, 2013/1216
- Alpha-Lipoic Acid;
- Oral Ethanol Self-Administration;
- Wistar Rats
The main system of central ethanol (EtOH) oxidation is mediated by the enzyme catalase. By reacting with H2O2, brain catalase forms compound I (the catalase-H2O2 system), which is able to oxidize EtOH to acetaldehyde (ACD) in the brain. We have previously shown that ACD regulates EtOH motivational properties and possesses reinforcing effects by itself. In this study, we investigate the effects of alpha-lipoic acid (ALA), a scavenging agent for H2O2, on oral EtOH self-administration.
To this end, we trained Wistar rats to orally self-administer EtOH (10%) by nose poking. The effect of intraperitoneal pretreatment with ALA was evaluated during (i) maintenance of EtOH self-administration, (ii) EtOH self-administration under a progressive ratio (PR) schedule of reinforcement, and (iii) oral EtOH priming to induce reinstatement of EtOH seeking behavior. Moreover, we tested the effect of ALA on saccharin (0.05%) reinforcement, as assessed by oral self-administration.
The results indicate that ALA dose-dependently reduced the maintenance, the break point of EtOH self-administration under a PR and the reinstatement of EtOH seeking behavior without suppressing saccharin self-administration.
These results support that ALA may have a potential use in alcoholism treatment.