Altered Neural Processing of Threat in Alcohol-Dependent Men
Version of Record online: 24 JUL 2013
Copyright © 2013 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 37, Issue 12, pages 2029–2038, December 2013
How to Cite
Yang, H., Devous, M. D., Briggs, R. W., Spence, J. S., Xiao, H., Kreyling, N. and Adinoff, B. (2013), Altered Neural Processing of Threat in Alcohol-Dependent Men. Alcoholism: Clinical and Experimental Research, 37: 2029–2038. doi: 10.1111/acer.12187
- Issue online: 3 DEC 2013
- Version of Record online: 24 JUL 2013
- Manuscript Accepted: 15 APR 2013
- Manuscript Received: 16 JAN 2013
- INIAStress. Grant Numbers: U01AA013641, U01AA16668, UL1TR000451
- VA North Texas Health Care System
- Homeward Bound, Inc.
- Anticipatory Anxiety;
- Functional Magnetic Resonance Imaging;
- Emotional Stress;
- Striatal–Limbic–Cortical System
Stress-response biological systems are altered in alcohol-dependent individuals and are reported to predict future relapse. This study was designed to assess neural disruptions in alcohol-dependent participants when exposed to a conditioned stimulus (CS) warning of the impending onset of a universal, nonpersonalized stressor.
Fifteen alcohol-dependent men abstinent for 3 to 5 weeks and 15 age- and race-similar healthy controls were studied. Anticipatory anxiety was induced by a CS paired with an uncertain, physically painful unconditioned stressor. Neural response was assessed using functional magnetic resonance imaging.
Both groups experienced significant, similar levels of anticipatory anxiety in response to the high-threat relative to the low-threat CS. Whereas control participants markedly increased the blood oxygen level-dependent (BOLD) amplitude in cortical–limbic–striatal regions during the high-threat, relative to low-threat, stimulus, alcohol-dependent participants decreased BOLD amplitude in the pregenual anterior cingulate cortex (pgACC), medial prefrontal cortex (mPFC), medial orbitofrontal cortex, posterior cingulate cortex (PCC), bilateral parietal/occipital cortex, and right hippocampus. Alcohol-dependent participants significantly deactivated pgACC/mPFC and PCC clusters, relative to controls, during the high- versus low-threat stimulus. This difference was due to a decrease in %BOLD amplitude during the high-threat stimulus in the alcohol-dependent, but not the control, participants.
Alcohol-dependent men show cortical–limbic–striatal deactivation during anticipatory anxiety, particularly in regions associated with emotional regulation. These findings suggest a lack of engagement of affective regulatory mechanisms during high-stress situations in alcohol-dependent men.