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References

  • Agarwal DP, Eckey R, Harada S, Goedde HW (1984) Basis of aldehyde dehydrogenase deficiency in Orientals: immunochemical studies. Alcohol 1:111118.
  • Brooks PJ, Enoch MA, Goldman D, Li TK, Yokoyama A (2009) The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med 6:e50.
  • Chao YC, Liou SR, Chung YY, Tang HS, Hsu CT, Li TK, Yin SJ (1994) Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. Hepatology 19:360366.
  • Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ (1999a) Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 65:795807.
  • Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321:14931495.
  • Chen YC, Lu RB, Peng GS, Wang MF, Wang HK, Ko HC, Chang YC, Lu JJ, Li TK, Yin SJ (1999b) Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol Clin Exp Res 23:18531860.
  • Chen YC, Peng GS, Tsao TP, Wang MF, Lu RB, Yin SJ (2009a) Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genomics 19:588599.
  • Chen YC, Peng GS, Wang MF, Tsao TP, Yin SJ (2009b) Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. Chem Biol Interact 178:27.
  • Chen Z, Stamler JS (2006) Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc Med 16:259265.
  • Chiang CP, Jao SW, Lee SP, Chen PC, Chung CC, Lee SL, Nieh S, Yin SJ (2012a) Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. Alcohol 46:3749.
  • Chiang CP, Wu CW, Lee SP, Chung CC, Wang CW, Lee SL, Nieh S, Yin SJ (2009) Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury. Alcohol Clin Exp Res 33:10591068.
  • Chiang CP, Wu CW, Lee SP, Ho JL, Lee SL, Nieh S, Yin SJ (2012b) Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine. Alcohol Clin Exp Res 36:20472058.
  • Crabb DW, Edenberg HJ, Bosron WF, Li TK (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest 83:314316.
  • Crabb DW, Matsumoto M, Chang D, You M (2004) Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 63:4963.
  • Enomoto N, Takase S, Yasuhara M, Takada A (1991) Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 15:141144.
  • Farres J, Wang X, Takahashi K, Cunningham SJ, Wang TT, Weiner H (1994) Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 269:1385413860.
  • Hempel J, Kaiser R, Jornvall H (1984) Human liver mitochondrial aldehyde dehydrogenase: a C-terminal segment positions and defines the structure corresponding to the one reported to differ in the Oriental enzyme variant. FEBS Lett 173:367373.
  • Higuchi S, Matsushita S, Imazeki H, Kinoshita T, Takagi S, Kono H (1994) Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343:741742.
  • Impraim C, Wang G, Yoshida A (1982) Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity. Am J Hum Genet 34:837841.
  • Kim DJ, Choi IG, Park BL, Lee BC, Ham BJ, Yoon S, Bae JS, Cheong HS, Shin HD (2008) Major genetic components underlying alcoholism in Korean population. Hum Mol Genet 17:854858.
  • Lai CL, Li YP, Liu CM, Hsieh HS, Yin SJ (2013) Inhibition of human alcohol and aldehyde dehydrogenases by cimetidine and assessment of its effects on ethanol metabolism. Chem Biol Interact 202:275282.
  • Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD (2007) Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. J Biol Chem 282:1294012950.
  • Lee SL, Shih HT, Chi YC, Li YP, Yin SJ (2011) Oxidation of methanol, ethylene glycol, and isopropanol with human alcohol dehydrogenases and the inhibition by ethanol and 4-methylpyrazole. Chem Biol Interact 191:2631.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265275.
  • Mizoi Y, Yamamoto K, Ueno Y, Fukunaga T, Harada S (1994) Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 29:707710.
  • Peng GS, Chen YC, Tsao TP, Wang MF, Yin SJ (2007) Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genomics 17:845855.
  • Peng GS, Wang MF, Chen CY, Luu SU, Chou HC, Li TK, Yin SJ (1999) Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 9:463476.
  • Peng GS, Yin SJ (2009) Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. Hum Genomics 3:121127.
  • Stagos D, Chen Y, Brocker C, Donald E, Jackson BC, Orlicky DJ, Thompson DC, Vasiliou V (2010) Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. Drug Metab Dispos 38:16791687.
  • Takase S, Takada A, Yasuhara M, Tsutsumi M (1989) Hepatic aldehyde dehydrogenase activity in liver diseases, with particular emphasis on alcoholic liver disease. Hepatology 9:704709.
  • Wang RS, Nakajima T, Kawamoto T, Honma T (2002) Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. Drug Metab Dispos 30:6973.
  • Xiao Q, Weiner H, Crabb DW (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 98:20272032.
  • Xiao Q, Weiner H, Johnston T, Crabb DW (1995) The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. J Clin Invest 96:21802186.
  • Yao CT, Lai CL, Hsieh HS, Chi CW, Yin SJ (2010) Establishment of steady-state metabolism of ethanol in perfused rat liver: the quantitative analysis using kinetic mechanism-based rate equations of alcohol dehydrogenase. Alcohol 44:541551.
  • Yao CT, Liao CS, Yin SJ (1997) Human hepatic alcohol and aldehyde dehydrogenases: genetic polymorphism and activities. Proc Natl Sci Counc Repub China 21B:106111.
  • Yin SJ, Liao CS, Wu CW, Li TT, Chen LL, Lai CL, Tsao TY (1997) Human stomach alcohol and aldehyde dehydrogenases: comparison of expression pattern and activities in alimentary tract. Gastroenterology 112:766775.
  • Yin SJ, Peng GS (2005) Overview of ALDH polymorphism: relation to cardiovascular effects of alcohol, in Comprehensive Handbook of Alcohol Related Pathology, Vol. 1 (Preedy VR, Watson RR eds), pp 409424. Elsevier, London.
  • Yoshida A, Dave V (1985) Enzymatic activity of atypical Oriental types of aldehyde dehydrogenases. Biochem Genet 23:585590.
  • Yoshida A, Huang IY, Ikawa M (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci USA 81:258261.
  • Zhou J, Weiner H (2000) Basis for half-of-the-site reactivity and the dominance of the K487 oriental subunit over the E487 subunit in heterotetrameric human liver mitochondrial aldehyde dehydrogenase. Biochemistry 39:1201912024.