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Infant Emotional Withdrawal: A Precursor of Affective and Cognitive Disturbance in Fetal Alcohol Spectrum Disorders

Authors

  • Christopher D. Molteno,

    Corresponding author
    1. Department of Psychiatry and Mental Health , Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    • Reprint requests: Sandra W. Jacobson, PhD, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Drive, Suite 2-C, Detroit, MI 48201; Tel.: 313-993-5454; Fax: 313-993-3427; E-mail: sandra.jacobson@wayne.edu and Christopher D. Molteno, MD, Department of Psychitary, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa; Tel.:+27-21-406-6291; fax:+27-21-406-6212; E-mail: molteno.chris@gmail.com

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  • Joseph L. Jacobson,

    1. Department of Psychiatry and Mental Health , Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    2. Department of Psychiatry and Behavioral Neurosciences , Wayne State University School of Medicine, Detroit, Michigan
    3. Department of Human Biology , Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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  • R. Colin Carter,

    1. Division of Pediatric Emergency Medicine , Columbia University College of Physicians and Surgeons, New York, New York
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  • Neil C. Dodge,

    1. Department of Psychiatry and Behavioral Neurosciences , Wayne State University School of Medicine, Detroit, Michigan
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  • Sandra W. Jacobson

    Corresponding author
    1. Department of Psychiatry and Mental Health , Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    2. Department of Psychiatry and Behavioral Neurosciences , Wayne State University School of Medicine, Detroit, Michigan
    3. Department of Human Biology , Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    • Reprint requests: Sandra W. Jacobson, PhD, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Drive, Suite 2-C, Detroit, MI 48201; Tel.: 313-993-5454; Fax: 313-993-3427; E-mail: sandra.jacobson@wayne.edu and Christopher D. Molteno, MD, Department of Psychitary, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa; Tel.:+27-21-406-6291; fax:+27-21-406-6212; E-mail: molteno.chris@gmail.com

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Abstract

Background

Our aim was to test the hypothesis that emotional withdrawal is an early indicator of affective disorder in infants heavily exposed prenatally to alcohol, which is independent of alcohol-related effects on mother–infant interaction and temperament and discriminated between children later diagnosed with fetal alcohol syndrome (FAS) and partial FAS (PFAS) and predicted cognitive and affective outcomes at 5 and 9 years.

Methods

The sample consisted of Cape Coloured (mixed ancestry) infants, whose mothers were interviewed during pregnancy regarding their alcohol consumption using a timeline follow-back approach. Infant emotional withdrawal (n = 85) was assessed on the Alarm Distress Baby Scale at 6.5 months. Mother–infant interaction was evaluated from video recordings during free play and infant feeding at 6.5 months (n = 127). Infant temperament was assessed by maternal report on the EAS Temperament Survey at 13 months (n = 119). Sociodemographic and psychological correlates of maternal alcohol use and infant iron deficiency were examined as potential confounders. The children were diagnosed for FAS/PFAS by expert dysmorphologists at 5 years, cognitive and affective function at 5 and 9 years.

Results

Prenatal alcohol exposure was associated with increased infant emotional withdrawal and decreased activity, but unrelated to mother–infant interaction or any other temperament measures. Children later diagnosed with FAS and PFAS at 5 years exhibited more emotional withdrawal and less responsivity and activity as infants. Infant withdrawal, responsivity, quality of interaction, and maternal sensitivity also predicted poorer IQ and affective response at 5 and 9 years. When all 4 infant affective measures were examined simultaneously in a regression analysis, only infant emotional withdrawal persisted as a significant predictor of 9-year IQ.

Conclusions

This study is the first to document a direct effect of fetal alcohol exposure on emotional withdrawal in infancy. These data link prenatal alcohol to a specific aspect of infant affective function not attributable to mother–infant interaction, infant temperament, or other socioemotional aspects of the infant's environment and identify infant emotional withdrawal as an early indicator of affective disturbance, particularly in children later diagnosed with FAS and PFAS.

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