Commentary: Indefensible Methods of Handling Missing Data in Clinical Trials
Article first published online: 18 OCT 2013
Copyright © 2013 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 37, Issue 12, pages 1997–1998, December 2013
How to Cite
Arndt, S. (2013), Commentary: Indefensible Methods of Handling Missing Data in Clinical Trials. Alcoholism: Clinical and Experimental Research, 37: 1997–1998. doi: 10.1111/acer.12294
- Issue published online: 3 DEC 2013
- Article first published online: 18 OCT 2013
- Manuscript Accepted: 7 SEP 2013
- Manuscript Received: 1 SEP 2013
- Missing Data;
- Alcohol Use Disorder;
- Clinical Trials
Literature continues to appear using inappropriate statistical methods when dealing with missing data in treatment trials. I regularly see last observation carried forward, assumed worst-case scenario, or some other static imputation method still being submitted and published in journals.
We briefly cover a few reasons why the use of more modern and defensible methods may not have completely saturated the literature.
While some delay in complete permeation of appropriate methods is understandable, we are currently past the point for reasonable delay.
Editors and reviewers should demand appropriate statistical methods in published literature.