Relationship Between Brain Volumetric Changes and Interim Drinking at Six Months in Alcohol-Dependent Patients
Article first published online: 31 JAN 2014
Copyright © 2014 by the Research Society on Alcoholism.
Alcoholism: Clinical and Experimental Research
Volume 38, Issue 3, pages 739–748, March 2014
How to Cite
Segobin, S. H., Chételat, G., Le Berre, A.-P., Lannuzel, C., Boudehent, C., Vabret, F., Eustache, F., Beaunieux, H. and Pitel, A.-L. (2014), Relationship Between Brain Volumetric Changes and Interim Drinking at Six Months in Alcohol-Dependent Patients. Alcoholism: Clinical and Experimental Research, 38: 739–748. doi: 10.1111/acer.12300
- Issue published online: 15 MAR 2014
- Article first published online: 31 JAN 2014
- Manuscript Accepted: 4 SEP 2013
- Manuscript Received: 21 MAY 2013
- Alcohol Dependence;
- Interim Drinking;
- Tensor-Based Morphometry;
- Brain Recovery
Chronic alcohol consumption results in brain damage potentially reversible with abstinence. It is however difficult to gauge the degree of recovery of brain tissues with abstinence since changes are subtle and a significant portion of patients relapse. State-of-the-art morphometric methods are increasingly used in neuroimaging studies to detect subtle brain changes at a voxel level. Our aim was to use the most refined morphometric methods to observe in alcohol dependence the relationship between volumetric changes and interim drinking over a 6-month follow-up.
Overall, 19 patients with alcohol dependence received volumetric T1-weighted magnetic resonance imaging (MRI) after detoxification. A 6-month follow-up study was then conducted, during which 11 of them received a second MRI scan. First, correlations were conducted between gray matter (GM) and white matter (WM) volumes of patients at alcohol treatment entry and the amount of alcohol consumed between treatment entry and follow-up. Second, longitudinal analyses were performed from pairs of MRI scans using tensor-based morphometry in the 11 patients, and correlations were computed between the resultant Jacobian maps of GM and WM and interim drinking.
Our preliminary results showed that, among others, alcoholics with smaller thalamus at alcohol treatment entry tended to resume with heavy alcohol consumption (p < 0.005 uncorrected [unc.]). Our longitudinal study revealed an overall inverse relationship between recovery of brain structures like the cerebellum, striatum, and cingulate gyrus, and the amount of alcohol consumed over the 6-month follow-up (p < 0.005 unc.). The recovery could be observed not only with strict abstinence but also in cases of moderate resumption of alcohol consumption, when there had been no drastic relapse into alcohol dependence.
Those preliminary findings indicate that the volume of the thalamus at treatment entry may have an influence on subsequent interim drinking. There is recovery of certain brain regions even when patients resume with moderate, but not drastic, alcohol consumption.