Association of the CHRNA4 Neuronal Nicotinic Receptor Subunit Gene with Frequency of Binge Drinking in Young Adults
Article first published online: 15 JAN 2014
Copyright © 2014 by the Research Society on Alcoholism
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Alcoholism: Clinical and Experimental Research
Volume 38, Issue 4, pages 930–937, April 2014
How to Cite
Coon, H., Piasecki, T. M., Cook, E. H., Dunn, D., Mermelstein, R. J., Weiss, R. B. and Cannon, D. S. (2014), Association of the CHRNA4 Neuronal Nicotinic Receptor Subunit Gene with Frequency of Binge Drinking in Young Adults. Alcoholism: Clinical and Experimental Research, 38: 930–937. doi: 10.1111/acer.12319
- Issue published online: 9 APR 2014
- Article first published online: 15 JAN 2014
- Manuscript Accepted: 14 OCT 2013
- Manuscript Received: 25 JUL 2013
- National Cancer Institute. Grant Number: P01CA098262
Fig. S1. Average genotypic frequency differences by race/ethnicity.
Fig. S2. 1KGP haplotypes, zoomed view at CHRNA4.
Table S1. List of all SNPs tested in this study, organized by gene or gene cluster and by chromosomal location.
Table S2. Descriptive characteristics of 702 participants with alcohol phenotypes.
Table S3. p-Values from PLINK multivariate tests of sets of SNPs defined by each nicotinic receptor gene or gene cluster with 2 levels of covariate adjustment.
Table S4. Individual univariate SNP tests with correlated alcohol quantity and frequency variables for CHRNA4 for maximum frequency and drink frequency.
Table S5. Set tests for binge frequency by Hispanic ethnicity.
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