Get access

Altered Anterior Cingulate Neurochemistry in Emerging Adult Binge Drinkers with a History of Alcohol-Induced Blackouts

Authors

  • Marisa M. Silveri,

    Corresponding author
    1. Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts
    2. McLean Imaging Center, McLean Hospital, Belmont, Massachusetts
    3. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    • Reprint requests: Marisa M. Silveri, McLean Imaging Center, McLean Hospital, 115 Mill St., Mailstop 204, Belmont, MA 02478; Tel.: 617-855-2920; Fax: 617-855-2770; E-mail: msilveri@mclean.harvard.edu

    Search for more papers by this author
  • Julia Cohen-Gilbert,

    1. Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts
    2. McLean Imaging Center, McLean Hospital, Belmont, Massachusetts
    3. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Search for more papers by this author
  • David J. Crowley,

    1. Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts
    2. McLean Imaging Center, McLean Hospital, Belmont, Massachusetts
    3. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Search for more papers by this author
  • Isabelle M. Rosso,

    1. McLean Imaging Center, McLean Hospital, Belmont, Massachusetts
    2. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    3. Center for Depression, Anxiety and Stress Research (IMR), McLean Hospital, Belmont, Massachusetts
    Search for more papers by this author
  • J. Eric Jensen,

    1. McLean Imaging Center, McLean Hospital, Belmont, Massachusetts
    2. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Search for more papers by this author
  • Jennifer T. Sneider

    1. Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts
    2. McLean Imaging Center, McLean Hospital, Belmont, Massachusetts
    3. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Search for more papers by this author

Abstract

Background

Binge alcohol consumption is associated with multiple neurobiological consequences, including altered neurophysiology, brain structure, and functional activation. Magnetic resonance spectroscopy (MRS) studies have demonstrated neurochemical alterations in the frontal lobe of alcohol users, although most studies focused on older, alcohol-dependent subjects.

Methods

In this study, neurochemical data were acquired using MRS at 4.0 Tesla from emerging adults (18 to 24 years old) who were binge alcohol drinkers (BD, n = 23) or light drinkers (LD, n = 31). Since binge drinking is also associated with increased prevalence of experiencing an alcohol-induced blackout, BD were stratified into alcohol-induced blackout (BDBO) and non-blackout (BDN) groups.

Results

Overall, BD had significantly lower gamma amino-butyric acid (GABA) and N-acetyl-aspartate (NAA) in the anterior cingulate cortex (ACC) than LD. When stratified by blackout history, BDBO also had lower ACC glutamate (Glu) than LD. No group differences in MRS metabolites were observed in the parietal-occipital cortex. Lower ACC GABA and Glu remained significant after accounting for lower gray matter content in BD, however, NAA differences were no longer evident. In addition, low ACC GABA levels were associated with greater alcohol use consequences, and worse response inhibition and attention/mental flexibility in BD.

Conclusions

These data indicate that binge drinking affects frontal lobe neurochemistry, more so in those who had experienced an alcohol-induced blackout. Characterization of the neurochemical profiles associated with binge alcohol consumption and blackout history may help identify unique risk factors for the later manifestation of alcohol abuse and dependence, in young individuals who are heavy, frequent drinkers, but who do not meet the criteria for alcohol abuse disorders.

Get access to the full text of this article

Ancillary