Cerebrospinal Fluid Monocyte Chemoattractant Protein-1 in Alcoholics: Support for a Neuroinflammatory Model of Chronic Alcoholism
Article first published online: 1 APR 2014
Published 2014. This article is a U.S. Government work and is in the public domain in the USA
Alcoholism: Clinical and Experimental Research
Volume 38, Issue 5, pages 1301–1306, May 2014
How to Cite
Umhau, J. C., Schwandt, M., Solomon, M. G., Yuan, P., Nugent, A., Zarate, C. A., Drevets, W. C., Hall, S. D., George, D. T. and Heilig, M. (2014), Cerebrospinal Fluid Monocyte Chemoattractant Protein-1 in Alcoholics: Support for a Neuroinflammatory Model of Chronic Alcoholism. Alcoholism: Clinical and Experimental Research, 38: 1301–1306. doi: 10.1111/acer.12367
- Issue published online: 22 APR 2014
- Article first published online: 1 APR 2014
- Manuscript Accepted: 17 DEC 2013
- Manuscript Received: 16 MAY 2013
- The Laboratory of Clinical and Translational Studies
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Mental Health
- Monocyte Chemoattractant Protein-1;
- Cerebrospinal Fluid;
Liver inflammation in alcoholism has been hypothesized to influence the development of a neuroinflammatory process in the brain characterized by neurodegeneration and altered cognitive function. Monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) elevations have been noted in the alcoholic brain at autopsy and may have a role in this process.
We studied cerebrospinal fluid (CSF) levels of MCP-1 as well as interleukin-1β and tumor necrosis factor-α in 13 healthy volunteers and 28 alcoholics during weeks 1 and 4 following detoxification. Serum liver enzymes were obtained as markers of alcohol-related liver inflammation.
Compared to healthy volunteers, MCP-1 levels were significantly higher in alcoholics both on day 4 and day 25 (p < 0.0001). Using multiple regression analysis, we found that MCP-1 concentrations were positively associated with the liver enzymes gamma glutamyltransferase (GGT; p = 0.03) and aspartate aminotransferase/glutamic oxaloacetic transaminase (AST/GOT; p = 0.004).
These preliminary findings are consistent with the hypothesis that neuroinflammation as indexed by CSF MCP-1 is associated with alcohol-induced liver inflammation, as defined by peripheral concentrations of GGT and AST/GOT.