Cardiac Reactivity During the Ascending Phase of Acute Intravenous Alcohol Exposure and Association with Subjective Perceptions of Intoxication in Social Drinkers
Article first published online: 21 MAR 2014
Published 2014. This article is a U.S. Government work and is in the public domain in the USA
Alcoholism: Clinical and Experimental Research
Volume 38, Issue 5, pages 1247–1254, May 2014
How to Cite
Vatsalya, V., Momenan, R., Hommer, D. W. and Ramchandani, V. A. (2014), Cardiac Reactivity During the Ascending Phase of Acute Intravenous Alcohol Exposure and Association with Subjective Perceptions of Intoxication in Social Drinkers. Alcoholism: Clinical and Experimental Research, 38: 1247–1254. doi: 10.1111/acer.12377
- Issue published online: 22 APR 2014
- Article first published online: 21 MAR 2014
- Manuscript Accepted: 14 JAN 2014
- Manuscript Received: 6 AUG 2013
- NIAAA Division of Intramural Clinical and Biological Research. Grant Number: 1Z01 AA000466
- Alcohol Clamp;
- Intravenous Infusion;
- Heart Rate;
- Heart Rate Variability;
- Subjective Perceptions
The aim of this study was to characterize cardiac reactivity measures, heart rate (HR), and heart rate variability (HRV), following acute intravenous (IV) alcohol administration and their association with subjective responses in social drinkers.
Twenty-four subjects (11 females) received IV alcohol infusions to attain and clamp the breath alcohol concentration (BrAC) at 50 mg% or placebo in separate sessions. Serial 5-minute cardiac recordings at baseline and during the infusion were analyzed to obtain frequency and time domain cardiac measures. Self-reported subjective perceptions were also obtained at the same time points.
HR showed significant decreases from baseline, while the HRV measure pNN50 showed steady increases during the ascending phase of alcohol infusion. HR was inversely correlated with pNN50 across time and treatment. There was a significant association of HR with subjective feelings of high, intoxication, feeling drug effects, and liking drug effects across time during the ascending phase.
Acute IV alcohol resulted in decreases in HR and increases in HRV consistent with autonomic parasympathetic activation. The association of these changes with subjective responses suggests that cardiac reactivity may serve as a physiological marker of subjective alcohol effects. This study broadens the understanding of acute cardiovascular effects of alcohol and clinically significant cardiac conditions such as arrhythmia and cardiomyopathy associated with chronic alcohol drinking.