Association Between HTR7 Genetic Polymorphisms and Alcohol Dependence, Using the Alcohol Use Disorders Identification Test (AUDIT)

Authors

  • Jeong-Hyun Kim,

    1. Department of Life Science, Sogang University, Seoul, Korea
    2. Research Institute for Basic Science, Sogang University, Seoul, Korea
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  • Byung-Lae Park,

    1. Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea
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  • Hyun Sub Cheong,

    1. Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea
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  • Joon Seol Bae,

    1. Laboratory of Translational Genomics, Samsung Medical Center, Samsung Genome Institute, Seoul, Korea
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  • Lyoung Hyo Kim,

    1. Department of Life Science, Sogang University, Seoul, Korea
    2. Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea
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  • Jee Wook Kim,

    1. Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea
    2. Burn Institute, Hallym University, Seoul, Korea
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  • Byoung Chul Lee,

    1. Burn Institute, Hallym University, Seoul, Korea
    2. Department of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University, Seoul, Korea
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  • Cheong Hoon Seo,

    1. Burn Institute, Hallym University, Seoul, Korea
    2. Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, Hallym University, Seoul, Korea
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  • Tae-Cheon Kang,

    1. Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Korea
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  • Sun-Hee Park,

    1. Keyo Medical Foundation, Keyo Hospital, Uiwang, Korea
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  • Ihn-Geun Choi,

    Corresponding author
    1. Burn Institute, Hallym University, Seoul, Korea
    2. Department of Neuropsychiatry, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea
    • Reprint requests: Dr. Ihn-Geun Choi, Department of Neuropsychiatry, Hallym University Kangnam Sacred Heart Hospital, 948-1 Daerim 1-Dong, Yeongdeungpo-Gu, Seoul 150-950, Korea; Tel.: 82-2-845-5194; Fax: 82-2-849-4469; E-mail: ihngeun@naver.com and

      Dr. Hyoung Doo Shin, Department of Life Science, Sogang University, Seoul, 121-742, Korea; Tel.: 82-2-705-8615; Fax: 82-2-3273-1680; E-mail: hdshin@sogang.ac.kr

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  • Hyoung Doo Shin

    Corresponding author
    1. Department of Life Science, Sogang University, Seoul, Korea
    2. Research Institute for Basic Science, Sogang University, Seoul, Korea
    • Reprint requests: Dr. Ihn-Geun Choi, Department of Neuropsychiatry, Hallym University Kangnam Sacred Heart Hospital, 948-1 Daerim 1-Dong, Yeongdeungpo-Gu, Seoul 150-950, Korea; Tel.: 82-2-845-5194; Fax: 82-2-849-4469; E-mail: ihngeun@naver.com and

      Dr. Hyoung Doo Shin, Department of Life Science, Sogang University, Seoul, 121-742, Korea; Tel.: 82-2-705-8615; Fax: 82-2-3273-1680; E-mail: hdshin@sogang.ac.kr

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Abstract

Background

A recent genome-wide association study has identified 5-hydroxytrytamine (serotonin) receptor 7, adenylate cyclase-coupled (HTR7) as a risk gene for alcohol dependence. In addition, the serotonergic system has been considered as a modulator that plays an important role in alcohol use disorders. Functional, pharmacological, and genetic studies of serotonin neurotransmission have revealed that serotonin receptors are potential targets for the treatment of alcohol use disorders. The aim of this study is to investigate whether associations between HTR7 genetic polymorphisms and alcohol dependence could be replicated.

Methods

This study genotyped a total of 22 common single nucleotide polymorphisms (SNPs) in 459 alcoholic patients and 444 nonalcoholic controls.

Results

Logistic regression analysis of the case–control study, controlling for age and sex as covariates, showed nominal associations of 7 SNPs (p = 0.02 to 0.04; odds ratio = 0.60 to 1.35). In further linear regression analysis based on the Alcohol Use Disorders Identification Test score for alcohol dependence, 8 SNPs and 3 haplotypes showed relatively significant associations with alcohol dependence (minimum p = 0.001; pcorr = 0.02).

Conclusions

Although further replications and functional evaluations are needed, our findings suggest that genetic variations of HTR7 may contribute to the predisposition for alcohol dependence.

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