Epidemiology, Diagnosis and Comorbidity
Prevalence of Alcohol-Interactive Prescription Medication Use Among Current Drinkers: United States, 1999 to 2010
Version of Record online: 16 JAN 2015
Copyright © 2015 by the Research Society on Alcoholism
Alcoholism: Clinical and Experimental Research
Volume 39, Issue 2, pages 371–379, February 2015
How to Cite
Breslow, R. A., Dong, C. and White, A. (2015), Prevalence of Alcohol-Interactive Prescription Medication Use Among Current Drinkers: United States, 1999 to 2010. Alcoholism: Clinical and Experimental Research, 39: 371–379. doi: 10.1111/acer.12633
- Issue online: 14 FEB 2015
- Version of Record online: 16 JAN 2015
- Manuscript Accepted: 6 NOV 2014
- Manuscript Received: 22 MAY 2014
- Alcohol Consumption;
- Drinking Patterns;
- Drinking Behavior;
- Prescription Medications;
- Cross-Sectional Survey;
- National Health and Nutrition Examination Survey
The majority of Americans consume alcoholic beverages. Alcohol interacts negatively with numerous commonly prescribed medications. Yet, on a population level, little is known about use of alcohol-interactive (AI) prescription medications among drinkers. The purpose of our study was to determine the prevalence of AI prescription medication use among current drinkers in the U.S. population.
Data were from the National Health and Nutrition Examination Survey (NHANES 1999 to 2010); 26,657 adults aged ≥20 years had data on past year alcohol consumption and past month prescription medication use. Analyses were adjusted for covariates: age, race/ethnicity, education, marital status, and smoking. Statistical procedures accounted for survey stratification, clustering, and nonresponse. Analyses were weighted to be nationally representative.
The unadjusted total prevalence of AI medication use was 42.8% (95% confidence interval [CI] 41.5 to 44.0). Among current drinkers, adjusted prevalence was 41.5% (CI 40.3 to 42.7). Among participants aged ≥65 total prevalence of AI medication use was 78.6% (CI 77.3 to 79.9) and adjusted prevalence among current drinkers was 77.8% (CI 75.7 to 79.7). The AI medications most commonly used by current drinkers were cardiovascular agents, central nervous system agents, and metabolic agents.
Our results suggest that there could be substantial simultaneous exposure to alcohol and AI prescription medications in the U.S. population. Given the adverse health risks of combining alcohol with AI prescription medications, future efforts are needed to collect data to determine actual simultaneous prevalence.