Alcoholism: Clinical and Experimental Research

Cover image for Vol. 40 Issue 10

October 2016

Volume 40, Issue 10

Pages 2025–2253

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. You have free access to this content
      Issue Information (pages 2025–2028)

      Version of Record online: 3 OCT 2016 | DOI: 10.1111/acer.12871

  2. Articles of Public Interest

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. Articles of Public Interest (page 2029)

      Version of Record online: 3 OCT 2016 | DOI: 10.1111/acer.13212

  3. Critical Reviews

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder (pages 2030–2042)

      Amy W. Lasek

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/acer.13200

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      Extracellular matrix (ECM) compartments in the brain. Ethanol alters the function of all three compartments. (A). Basement membrane located on the basolateral side of endothelial cells of blood vessels is part of the blood–brain barrier (B). Interstitial matrix is found between neuronal and glial cells of the brain parenchyma. Regulation of ECM is controlled by proteases such as the matrix metalloproteinases (MMPs) and affects synaptic plasticity. (C). Perineuronal nets form lattice-like structures around neurons and also regulate neuronal activity.

    2. Alcohol Policies and Suicide: A Review of the Literature (pages 2043–2055)

      Ziming Xuan, Timothy S. Naimi, Mark S. Kaplan, Courtney L. Bagge, Lauren R. Few, Stephen Maisto, Richard Saitz and Robert Freeman

      Version of Record online: 12 SEP 2016 | DOI: 10.1111/acer.13203

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      The figure shows a shift of the distribution of population suicide risk to a favorable (lower) direction through better implementation of effective alcohol policies. By making alcohol less available at the population level, it is possible to reduce the average risk of suicide especially those where alcohol is involved. Consistent with the prevention paradox, this population-based approach is likely to maximize public health benefit and have a long-lasting influence on reducing suicide and related social burden.

    3. Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions (pages 2056–2072)

      Emily C. Williams, Judith A. Hahn, Richard Saitz, Kendall Bryant, Marlene C. Lira and Jeffrey H. Samet

      Version of Record online: 22 SEP 2016 | DOI: 10.1111/acer.13204

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      This narrative review finds that alcohol use is associated with HIV acquisition and transmission, lack of viral suppression, common comorbid conditions (e.g., hepatitis C, tuberculosis, cardiovascular disease, frailty/falls, depression, trauma, and other substance use disorders), and ultimately mortality among people living with HIV (PLWH). Associations between alcohol use and HIV-related care and outcomes may disproportionately affect vulnerable subgroups of PLWH. Interventions to address drinking and subsequently improve HIV-related risks and outcomes have been tested with limited success to date.

  4. Commentary

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
  5. Biochemistry, Pharmacology, Physiology and Metabolism

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice (pages 2076–2084)

      Qian Sun, Wenliang Zhang, Wei Zhong, Xinguo Sun and Zhanxiang Zhou

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/acer.13172

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      Dietary fisetin supplementation ameliorated chronic alcohol exposure-induced liver injury in mice. Fisetin accelerated alcohol clearance, upregulated fatty acid oxidation enzymes, and suppressed oxidative stress. These fisetin actions were associated with increased aldehyde dehydrogenase activity, enhanced adiponectin-AMPK signaling transduction, and reduced NOX4 in the liver. The results suggest that fisetin has a therapeutic potential for treating alcoholic liver disease.

    2. Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients (pages 2085–2093)

      Vatsalya Vatsalya, Ming Song, Melanie L. Schwandt, Matthew C. Cave, Shirish S. Barve, David T. George, Vijay A. Ramchandani and Craig J. McClain

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/acer.13197

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      EPA levels were significantly increased in male alcohol-dependent patients who exhibited mild liver injury; however, there was no response change in females. On the other hand, DHA levels were reduced in females who exhibited mild liver injury, while in males with mild liver injury, there was an increase in DHA levels supporting protective or anti-inflammatory response.

  6. Cell and Molecular Biology

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1 (pages 2094–2101)

      Bruno Christian Koehler, Tatjana Arslic-Schmitt, Theresa Peccerella, Anna-Lena Scherr, Henning Schulze-Bergkamen, Thomas Bruckner, Georg Gdynia, Dirk Jäger, Sebastian Mueller, Helmut Bartsch and Helmut K. Seitz

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/acer.13180

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      Chronic alcohol consumption is a risk factor for colorectal cancer. In 32 colorectal biopsies from alcoholics and 12 from control patients, no significant difference between CYP2E1 levels as well as mutagenic etheno-DNA adducts was observed. Both CYP2E1 and etheno-DNA adducts correlate significantly with each other (p < 0.0001). Although apoptosis was not affected, the anti-apoptotic protein Mcl-1 was significantly increased in the alcoholic, which gives injured cells a survival benefit and may be one mechanism in alcohol-mediated colorectal carcinogenesis.

    2. Interactive Effects of Ethanol and HIV-1 Proteins on Novelty-Seeking Behaviors and Addiction-Related Gene Expression (pages 2102–2113)

      Taylor Wingo, Tanseli Nesil, Sulie L. Chang and Ming D. Li

      Version of Record online: 21 SEP 2016 | DOI: 10.1111/acer.13206

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      HIV-1 proteins may alter the function of central reward in the nucleus accumbens by modulating expression of neurotransmitter receptors implicated in both novelty-seeking behavior and alcohol addiction. This study suggests that HIV-1 infection leads to increased vulnerability to addiction compared with the general population. HIV-1 proteins increased novelty-seeking behavior and ethanol enhanced this behavior in both the control and HIV-1Tg rats. This figure summarizes the effects of HIV-1 proteins and chronic ethanol treatment on neurotransmission in the NAc.

  7. Neuroscience

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. Accumbal μ-Opioid Receptors Modulate Ethanol Intake in Alcohol-Preferring Alko Alcohol Rats (pages 2114–2123)

      Johanna Uhari-Väänänen, Atso Raasmaja, Pia Bäckström, Ville Oinio, Mikko Airavaara, Petteri Piepponen and Kalervo Kiianmaa

      Version of Record online: 10 AUG 2016 | DOI: 10.1111/acer.13176

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      The opioidergic system has been implicated in the control of ethanol (EtOH) intake and reward. However, the exact mechanisms of opioidergic involvement remain to be elucidated. In this study, alcohol-preferring AA rats received intra-accumbal microinfusions of drugs acting on μ- and κ-opioid receptors and their effects on acute EtOH intake were monitored. The μ-opioid receptor antagonist CTOP increased and agonist DAMGO tended to decrease EtOH intake. The results suggest that accumbal μ- but not κ-opioid receptors participate in controlling EtOH intake.

    2. Electrophysiological and Behavioral Effects of Combined Transcranial Direct Current Stimulation and Alcohol Approach Bias Retraining in Hazardous Drinkers (pages 2124–2133)

      Tess E. den Uyl, Thomas E. Gladwin and Reinout W. Wiers

      Version of Record online: 25 AUG 2016 | DOI: 10.1111/acer.13171

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      In this study, we investigated a combination of two innovative interventions: cognitive bias modification (CBM) and transcranial direct current stimulation (tDCS), in hazardous drinkers. There were no electrophysiological or behavioral effects of repeated CBM and/or tDCS, except for a small effect of tDCS on craving. Applied in these specific ways, these techniques appear to have limited effects in a hazardous drinking population. Important considerations for future research are discussed.

    3. Moderate Prenatal Alcohol Exposure Alters Functional Connectivity in the Adult Rat Brain (pages 2134–2146)

      Carlos I. Rodriguez, Suzy Davies, Vince Calhoun, Daniel D. Savage and Derek A. Hamilton

      Version of Record online: 29 AUG 2016 | DOI: 10.1111/acer.13175

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      The effects of moderate prenatal alcohol exposure (PAE) on specific brain regions, neurotransmitters, and behaviors have received considerable attention. In contrast, the effects of moderate PAE on whole-brain functional network connectivity (FNC) remain under-represented in the animal literature. Here, we report that moderate PAE contributes to persistent brain region- and sex-dependent changes in FNC in anesthetized rats. Understanding FNC changes may contribute to the development of novel approaches for understanding fetal alcohol spectrum disorders and evaluating potential treatment strategies.

  8. Pathology, Immunology and Development

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. The Relationship Between Airway Antioxidant Levels, Alcohol Use Disorders, and Cigarette Smoking (pages 2147–2160)

      Ellen L. Burnham, Alicia McNally, Jeanette Gaydos and Lou Ann S. Brown

      Version of Record online: 14 SEP 2016 | DOI: 10.1111/acer.13201

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      Bronchoscopy with bronchoalveolar lavage (BAL) was performed in otherwise healthy, smoking-matched subjects with alcohol use disorders and controls. Thiol quantities (including glutathione and cysteine species) in the initial 50-ml aliquot of BAL were determined to parallel quantities in subsequently collected BAL aliquots (Figure), suggesting that a small volume BAL procedure may be suitable to assess pulmonary oxidative stress within the alveoli. Alcohol use disorders and cigarette smoking modestly increased upper airways oxidative stress relative to lower.

  9. Epidemiology, Diagnosis and Comorbidity

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. Hospital Admissions Before an Alcohol-Related Death Among Middle-Aged Employed Men and Women: A Cohort Study Using Routine Data (pages 2161–2168)

      Tapio Paljärvi, Pekka Martikainen, Jussi Vahtera, Taina Leinonen and Pia Mäkelä

      Version of Record online: 18 AUG 2016 | DOI: 10.1111/acer.13183

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      We found that the majority of the middle-aged persons who were in employment at the age of 35 and who ultimately died due to alcohol-related causes at ages 45–54 interacted with hospitals frequently and already several years before death. However, because only a relative small proportion of these persons received an alcohol-related diagnosis before death, it should be established whether procedures enhancing the recording of alcohol-related diagnoses could facilitate timely management of problem drinking at hospitals.

    2. Trends and Correlates of Disparities in Alcohol-Related Mortality Between Hispanics and Non-Hispanic Whites in the United States, 1999 to 2014 (pages 2169–2179)

      Maria C. Mejia de Grubb, Jason L. Salemi, Sandra J. Gonzalez, Roger J. Zoorob and Robert S. Levine

      Version of Record online: 25 AUG 2016 | DOI: 10.1111/acer.13182

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      Population-based multiple cause of death data were used to describe temporal trends of alcohol-related mortality between Hispanics and NH whites in the United States. This figure, particularly the boxed inset, shows that although the gap in alcohol-related mortality between NH white and Hispanic women increased from 1999 to 2014, the same disparity among men, which was pronounced in earlier years, was eliminated by 2012. The understanding of factors associated with changing disparities may assist in tailoring prevention efforts that meet the needs of minority populations.

  10. Behavior, Treatment and Prevention

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. Do Alcohol Relapse Episodes During Treatment Predict Long-Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse (pages 2180–2189)

      Stephen A. Maisto, Corey R. Roos, Kevin A. Hallgren, Dezarie Moskal, Adam D. Wilson and Katie Witkiewitz

      Version of Record online: 3 SEP 2016 | DOI: 10.1111/acer.13173

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      This study tested the power of seven definitions of during-treatment “relapse” based on drinking quantity within a single drinking episode to predict alcohol use and psychosocial end of treatment and 12-month post-treatment outcomes. Secondary analyses of data from Projects MATCH and COMBINE were conducted. No definition of relapse stood out as the best predictor. Advances in AUD research may require reconceptualization of relapse as a multifaceted dynamic process when examining AUD clinical course.

    2. Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis (pages 2190–2198)

      Jeffrey D. Wardell, Vijay A. Ramchandani and Christian S. Hendershot

      Version of Record online: 16 AUG 2016 | DOI: 10.1111/acer.13174

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      This study examined the associations between drinking motives and subjective responses to alcohol during an intravenous alcohol session (target BAC = 80 mg%). Enhancement motives predicted greater stimulation and less sedation, whereas coping motives predicted greater sedation. Stimulation mediated the associations of enhancement motives with alcohol wanting and liking, whereas coping motives were directly associated with wanting and liking. Results suggest that drinking motives are linked with sensitivity to alcohol's subjective effects, which may underlie state motivation to consume alcohol at the event level.

    3. Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake (pages 2199–2207)

      Camilla Karlsson, Abdul Maruf Asif Aziz, Faazal Rehman, Caleb Pitcairn, Riccardo Barchiesi, Estelle Barbier, Mikaela Wendel Hansen, Don Gehlert, Pia Steensland, Markus Heilig and Annika Thorsell

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/acer.13181

    4. Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake (pages 2208–2217)

      Sandra Sanchez-Roige, David N. Stephens and Theodora Duka

      Version of Record online: 26 AUG 2016 | DOI: 10.1111/acer.13184

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      Young adults (18–33 years old) with a family history of alcoholism exhibited a different pattern of impulsive behaviour from family history negative individuals, showing greater waiting impulsivity, but less impulsivity during decision making. Under alcohol (0.8 g/kg), they were also less able to stop an already-initiated response. Importantly, individual alcohol drinking history did not contribute to this effect. Increased waiting impulsivity may be useful in assessing premorbid risk for heavy drinking and one that may be modified by acute alcohol intake.

    5. Addressing Inconsistencies in the Social Norms Drinking Literature: Development of the Injunctive Norms Drinking and Abstaining Behaviors Questionnaire (pages 2218–2228)

      Samuel N. Meisel, Craig R. Colder and Jennifer P. Read

      Version of Record online: 12 SEP 2016 | DOI: 10.1111/acer.13202

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      Motivated by inconsistent associations between injunctive norms (INs) and drinking outcomes, this study developed a new measure of INs (the IN Drinking and Abstaining Behaviors Questionnaire) that addressed psychometric weaknesses of prior measures. Analysis supported a three-factor solution and the IN Drinking Behaviors factor consistently predicted drinking outcomes across three referents. Findings suggest that prior inconsistencies in the relationship between INs and drinking are attributable to poor measurement of INs and that INs are a robust correlate of drinking.

    6. Parameters of Context-Induced Ethanol (EtOH)-Seeking in Alcohol-Preferring (P) Rats: Temporal Analysis, Effects of Repeated Deprivation, and EtOH Priming Injections (pages 2229–2239)

      Sheketha R. Hauser, Gerald A. Deehan Jr, Christopher P. Knight, Jamie E. Toalston, William J. McBride and Zachary A. Rodd

      Version of Record online: 22 SEP 2016 | DOI: 10.1111/acer.13205

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      Alcohol craving in humans can lead to alcohol relapse. Factors influencing alcohol craving include time from last drink, the number of cycles of alcohol abuse and abstinence, and unintentional exposure to alcohol. This research examined human factors in a rodent model of alcohol craving. The data indicated that alcohol craving in rats is greatest during the 6th week of abstinence, is enhanced in rats given multiple cycles of alcohol abuse and abstinence, and that priming with alcohol increases alcohol craving. Depicts the expression of alcohol craving during 1-, 2-, 4-, 6- or 8-weeks of abstinence. Alcohol craving in rats was enhanced during 2-, 4-, 6- and 8-weeks of abstinence and the expression of alcohol craving was the greatest during the 6th week of abstinence. In addition, the expression of alcohol craving remains elevated on the 2nd test day during 4- and 6-weeks of abstinence.

    7. Neighborhood-Level Drinking Norms and Alcohol Intervention Outcomes in HIV Patients Who Are Heavy Drinkers (pages 2240–2246)

      Jennifer C. Elliott, Erin Delker, Melanie M. Wall, Tianshu Feng, Efrat Aharonovich, Melissa Tracy, Sandro Galea, Jennifer Ahern, Aaron L. Sarvet and Deborah S. Hasin

      Version of Record online: 20 AUG 2016 | DOI: 10.1111/acer.13198

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      Using a sample of HIV-infected heavy drinkers, this study evaluated whether effects of two alcohol interventions (Motivational Interviewing [MI] alone or supplemented with an interactive technological enhancement called Healthcall) varied according to acceptability of drinking in participants’ neighborhoods. Results suggested that the efficacy of MI alone differed according to neighborhood norms, with MI alone only demonstrating effects in more permissive neighborhoods. The efficacy of MI + HealthCall did not vary by neighborhood, suggesting more robust effects of this intervention on drinking reduction.

      Intervention effects at selected levels of neighborhood unacceptability of drinking: Illustration of significant interaction between neighborhood drinking norm and intervention condition on drinks per drinking day.

    8. Effects of the GLP-1 Agonist Exendin-4 on Intravenous Ethanol Self-Administration in Mice (pages 2247–2252)

      Gunnar Sørensen, S. Barak Caine and Morgane Thomsen

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/acer.13199

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      A glucagon-like peptide 1 receptor agonist, Exendin-4, can powerfully attenuate voluntary ethanol intake by directly modulating the reinforcing effects of ethanol in intravenous self-administration in mice. These findings support the potential usefulness of GLP-1 receptor ligands in the treatment of alcohol use disorder.

  11. Erratum

    1. Top of page
    2. Issue Information
    3. Articles of Public Interest
    4. Critical Reviews
    5. Commentary
    6. Biochemistry, Pharmacology, Physiology and Metabolism
    7. Cell and Molecular Biology
    8. Neuroscience
    9. Pathology, Immunology and Development
    10. Epidemiology, Diagnosis and Comorbidity
    11. Behavior, Treatment and Prevention
    12. Erratum
    1. You have free access to this content
      Erratum (page 2253)

      Version of Record online: 20 SEP 2016 | DOI: 10.1111/acer.13236

      This article corrects:

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