Acta Psychiatrica Scandinavica

Cover image for Acta Psychiatrica Scandinavica

June 1989

Volume 80, Issue S350

Pages 6–159

  1. Original Article

    1. Top of page
    2. Original Article
    1. Opening remarks (page 6)

      P. Turner

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07158.x

    2. Serotonin function in affective disorders (pages 7–12)

      D.G. Grahame-Smith

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07159.x

    3. Introduction to the development of paroxetine, a novel antidepressant (page 13)

      J. Buus Lassen

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07160.x

    4. An overview of the animal pharmacology of paroxetine (pages 14–20)

      A. M. Johnson

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07161.x

    5. Pharmacological effects of paroxetine after repeated administration to animals (pages 21–23)

      D.R. Nelson, D.R. Thomas and A.M. Johnson

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07162.x

    6. Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites (pages 24–26)

      R.E. Haddock, A.M. Johnson, P.F. Langley, D.R. Nelson, J.A. Pope, D.R. Thomas and F.R. Woods

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07163.x

    7. Relative lack of cardiotoxicity of paroxetine in animal models (pages 27–30)

      C.R. Cain, T.C. Hamilton, J. Norton, E.N. Petersen, R.H. Poyser and D. Thormählen

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07164.x

    8. Comparative acute toxicity of paroxetine and other antidepressants (pages 31–33)

      A.S. Kelvin and S. Hakansson

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07165.x

    9. General and genetic toxicology of paroxetine (pages 34–36)

      A.S. Kelvin, I. de G. Mitchell and D.J. White

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07166.x

    10. The reproductive toxicology of paroxetine (pages 37–39)

      J.A. Baldwin, E.J. Davidson, A.L. Pritchard and J.E. Ridings

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07167.x

    11. Immunological evaluation of paroxetine (page 40)

      D.C. Henderson, R.G. Edwards, B.J. Weston and J.M. Dewdney

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07168.x

    12. Cardiovascular and psychomotor effects of repeated doses of paroxetine: a comparison with amitriptyline and placebo in healthy men (pages 42–44)

      S.J. Warrington, J. Dana-Haeri and A.J. Sinclair

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07169.x

    13. The clinical pharmacology of paroxetine in healthy subjects (pages 46–48)

      P. Raptopoulos, G.R. McClelland and D. Jackson

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07171.x

    14. Paroxetine: lack of effect on the tyramine pressor response in man (page 49)

      S.M. Hassan, G. Wainscott and P. Turner

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07172.x

    15. The effect of paroxetine on the quantitative EEG (pages 50–52)

      G.R. McClelland, P. Raptopoulos and D. Jackson

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07173.x

    16. The psychomotor effects of paroxetine alone and in combination with haloperidol, amylobarbitone, oxazepam, or alcohol (pages 53–55)

      S.M. Cooper, D. Jackson, J.M. Loudon, G.R. McClelland and P. Raptopoulos

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07174.x

    17. Regional distribution of serotonergic pre- and postsynaptic markers in human brain (pages 56–59)

      M. Laruelle and J.M. Maloteaux

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07175.x

    18. A review of the metabolism and pharmacokinetics of paroxetine in man (pages 60–75)

      C.M. Kaye, R.E. Haddock, P.F. Langley, G. Mellows, T.C.G. Tasker, B.D. Zussman and W.H. Greb

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07176.x

    19. Paroxetine: pharmacokinetic and antidepressant effect in the elderly (pages 76–80)

      J. Lundmark, I.Scheel Thomsen, T. Fjord-Larsen, P.M. Manniche, H. Mengel, E.M. Møller-Nielsen, H. Pauser and J. Wålinder

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07177.x

    20. A pharmacokinetic dose titration study in adult and elderly depressed patients (pages 81–84)

      G.F. Hebenstreit, K. Fellerer, R. Zöchling, A. Zentz and G.C. Dunbar

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07178.x

    21. The pharmacokinetics of paroxetine in the elderly (pages 85–86)

      A. J. Bayer, N. A. Roberts, E. A. Allen, M. Horan, P. A. Routledge, C. G. Swift, M. M. Byrne, A. Clarkson and B. D. Zussman

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07179.x

    22. The pharmacokinetics of paroxetine in elderly depressed patients (pages 87–88)

      K. Ghose

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07180.x

    23. The pharmacokinetics of paroxetine in renal impairment (pages 89–90)

      G. D. Doyle, M. Laher, J. G. Kelly, M. M. Byrne, A. Clarkson and B. D. Zussman

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07181.x

    24. The pharmacokinetics of paroxetine in patients with liver cirrhosis (pages 91–92)

      Z. Krastev, D. Terziivanov, V. Vlahov, A. Maleev, W. H. Greb, K. M. Eckl, H.-D. Dierdorf and D. Wolf

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07182.x

    25. Paroxetine: lack of effect on hepatic drug metabolizing enzymes (pages 93–94)

      R. E. Haddock, D. Jackson and F. R. Woods

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07183.x

    26. The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine (pages 95–98)

      W. H. Greb, G. Buscher, H.-D. Dierdorf, F. E. Köster, D. Wolf and G. Mellows

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07184.x

    27. Absorption of paroxetine under various dietary conditions and following antacid intake (pages 99–101)

      W. H. Greb, M. A. Brett, G. Buscher, H.-D. Dierdorf, H. W. von Schrader, D. Wolf, G. Mellows and B. D. Zussman

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07185.x

    28. Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin (pages 102–106)

      S. J. Bannister, V. P. Houser, J. D. Hulse, J. C. Kisicki and J. G. C. Rasmussen

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07186.x

    29. New antidepressants and 5-HT uptake inhibitors (pages 107–116)

      S.A. Montgomery

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07187.x

    30. A placebo-controlled, double-blind, clinical trial of paroxetine in depressed outpatients (pages 117–123)

      K. Rickels, J. Amsterdam, C. Clary, I. Fox, E. Schweizer and C. Weise

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07188.x

    31. The effect of paroxetine on the electroencephalogram, electrocardiogram, and blood pressure (page 124)

      J.G. Edwards, A. Goldie, S. Papayanni-Papasthatis, J. Punter and E.M. Sedgwck

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07189.x

    32. Paroxetine in the treatment of depression: a comparison with imipramine and placebo (pages 125–129)

      J.P. Feighner and W.F. Boyer

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07190.x

    33. A double-blind, multicentre study of paroxetine versus clomipramine in depressed elderly patients (pages 132–134)

      E. Guillibert, Y. Pelicier, J.C. Archambault, J.P. Chabannes, G. Cierc, M. Desvilles, M. Guibert, R. Pagot, J.L. Poisat and Y. Thobie

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07192.x

    34. An interim overview of the safety and tolerability of paroxetine (pages 135–137)

      G.C. Dunbar

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07193.x

    35. A double-blind, multicentre study of paroxetine and mianserin in depression (page 140)

      C. Mertens and H. Pintens

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07195.x

    36. A double-blind comparison of paroxetine and placebo in the treatment of depressed patients in a psychiatric outpatient clinic (pages 143–144)

      S.M. Miller, G.J. Naylor, M. Murtagh and G. Winslow

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07197.x

    37. A double-blind study of the comparative antidepressant effect of paroxetine and amitriptyline (pages 145–146)

      H. Kuhs and G.A.E. Rudolf

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07198.x

    38. Antidepressants and the peripheral nervous system (pages 147–148)

      I.W. Husstedt, H. Kuhs, G.A.E. Rudolf and G.G. Brune

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07199.x

    39. Platelet 5-HT transport in depressed patients under double-blind treatment with paroxetine versus amitriptyline (pages 149–151)

      H.-P. Schlake, H. Kuhs, L.H. Rolf, T. Bosse, E. Schuhknecht, G.A.E. Rudolf and G.G. Brune

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07200.x

    40. Paroxetine plasma levels: lack of correlation with efficacy or adverse events (pages 152–155)

      T.C.G. Tasker, C.M. Bye, B.D. Zussman and C.G.G. Link

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07201.x

    41. Ability of charcoal to prevent absorption of paroxetine (pages 156–157)

      W.H. Greb, G. Buscher, H.-D. Dierdorf, H.W. von Schrader and And D. Wolf

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07202.x

    42. Concluding remarks (pages 158–159)

      J. Wålinder

      Article first published online: 23 AUG 2007 | DOI: 10.1111/j.1600-0447.1989.tb07203.x

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