Effects of tryptophan depletion on reactive aggression and aggressive decision-making in young people with ADHD
Article first published online: 22 AUG 2012
© 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Special Issue: “Acute Tryptophan Depletion in Translational Psychiatric Research”, GUEST EDITOR Florian Daniel Zepf
Volume 128, Issue 2, pages 114–123, August 2013
How to Cite
Kötting, W. F., Bubenzer, S., Helmbold, K., Eisert, A., Gaber, T. J. and Zepf, F. D. (2013), Effects of tryptophan depletion on reactive aggression and aggressive decision-making in young people with ADHD. Acta Psychiatrica Scandinavica, 128: 114–123. doi: 10.1111/acps.12001
- Issue published online: 7 JUL 2013
- Article first published online: 22 AUG 2012
- Accepted for publication July 9, 2012
- attention deficit hyperactivity disorder;
- point subtraction aggression game;
- acute tryptophan depletion;
Kötting WF, Bubenzer S, Helmbold K, Eisert A, Gaber TJ, Zepf FD. Effects of tryptophan depletion on reactive aggression and aggressive decision-making in young people with ADHD.
Objective: The neurotransmitter serotonin (5-HT) has been linked to the underlying biological processes related to aggressive behaviour. However, only a few studies on this subject involving young people have been published so far.
Method: We aimed to investigate the effects of acute tryptophan depletion (ATD) on reactive aggression and decision-time for aggressive responses in a sample of young people with Attention deficit hyperactivity disorder (n = 20), a population at risk for aggressive behaviour. The study design was a double-blind within-subject crossover design. Aggression was assessed using a Point subtraction aggression game (PSAG) with high (HP) and low provocation (LP) trials 2.5 h after the intake of ATD and a tryptophan-balanced control condition.
Results: A chi-square comparison was used to identify the effect of ATD on increased aggression after LP. Boys were more likely to respond with an increased aggressive response after HP under ATD as represented by an increased relative risk and odds ratios. Girls had a higher relative risk than boys of an increased point subtraction under ATD after LP. No significant gender differences in decision-time were detected.
Conclusion: An effect of ATD on increased aggression was found in the whole sample after LP. Research involving larger samples is needed to confirm the present preliminary findings.