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Occupational disability in bipolar disorder: analysis of predictors of being on severe disablement benefit (PREBIS study data)

  1. I. Grande1,
  2. J. M. Goikolea1,
  3. C. de Dios2,
  4. A. González-Pinto3,
  5. J. M. Montes4,
  6. J. Saiz-Ruiz5,
  7. E. Prieto6,
  8. E. Vieta1,
  9. for the PREBIS group

Article first published online: 23 AUG 2012

DOI: 10.1111/acps.12003

Issue

Acta Psychiatrica Scandinavica

Acta Psychiatrica Scandinavica

Volume 127, Issue 5, pages 403–411, May 2013

Additional Information

How to Cite

Grande, I., Goikolea, J. M., de Dios, C., González-Pinto, A., Montes, J. M., Saiz-Ruiz, J., Prieto, E., Vieta, E. and for the PREBIS group (2013), Occupational disability in bipolar disorder: analysis of predictors of being on severe disablement benefit (PREBIS study data). Acta Psychiatrica Scandinavica, 127: 403–411. doi: 10.1111/acps.12003

Author Information

  1. 1

    Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain

  2. 2

    Department of Psychiatry, University Hospital La Paz, IDIPAZ, Madrid, Spain

  3. 3

    Hospital Santiago Apóstol, University of the Basque Country, Vitoria, CIBERSAM, Spain

  4. 4

    Hospital del Sureste, Arganda del Rey, Spain

  5. 5

    Department of Psychiatry, Ramon y Cajal University Hospital, IRYCIS, CIBERSAM University of Alcala, Madrid, Spain

  6. 6

    Neurosciences, Medical Department AstraZeneca Farmacéutica, Spain

*Eduard Vieta, Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic, Villarroel170, 08036-Barcelona, Spain. E-mail: evieta@clinic.ub.es

Publication History

  1. Issue published online: 15 APR 2013
  2. Article first published online: 23 AUG 2012
  3. Accepted for publication July 10, 2012

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Keywords:

  • bipolar disorder;
  • employment;
  • occupational adjustment;
  • outcome;
  • disability insurance;
  • clinical trial

Grande I, Goikolea JM, de Dios C, González-Pinto A, Montes JM, Saiz-Ruiz J, Prieto E, Vieta E, for the PREBIS group. Occupational disability in bipolar disorder: analysis of predictors of being on severe disablement benefit PREBIS study data).

Objective:  Patients diagnosed with bipolar disorder (BD) are reported to have significant work impairment during interepisode intervals. This study was carried out to assess potential predictors of occupational disability in a longitudinal follow-up of euthymic patients.

Method:  We included 327 euthymic patients diagnosed with BD type I or type II, 226 of whom were employed and 101 were receiving a severe disablement benefit (SDB). Sociodemographic data were studied and episode recurrence was assessed along a 1-year follow-up. Logistic regression analysis was applied to determine predictors of receiving SDB. Cox regression was built to study recurrences.

Results:  Predictors of receiving SDB were: axis II comorbidity [Odds Ratio (OR) = 2.94, CI: 1.26–6.86, P = 0.013], number of manic episodes (OR = 1.21, CI: 1.10–1.34, P < 0.001), being without stable partner (OR = 2.44, CI: 1.34–4.44, P = 0.004) and older age (OR = 1.08, CI: 1.05–1.12, P < 0.001). Bipolar patients receiving SDB presented more episodic recurrences regardless of polarity than employed bipolar patients (P = 0.002). The time until recurrence in 25% of the bipolar patients receiving SDB was 6.08 months (CI: 4.44–11.77) being 13.08 months (CI: 9.60 to –) in the employed group.

Conclusion:  Occupational disability in bipolar patients is associated with axis II comorbidity, more previous manic episodes, not having a stable relationship, older age, and more recurrences at 1-year follow-up.

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