• 1
    Chua SE, Cheung C, Cheung V et al. Cerebral grey, white matter and csf in never medicated, first-episode schizophrenia. Schizophr Res 2007;89:1221.
  • 2
    Kaspárek T, Prikryl R, Mikl M, Schwarz D, Cesková E, Krupa P. Prefrontal but not temporal grey matter changes in males with first-episode schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:151157.
  • 3
    Meisenzahl EM, Koutsouleris N, Bottlender R et al. Structural brain alterations at different stages of schizophrenia: a voxel-based morphometric study. Schizophr Res 2008;104:4460.
  • 4
    Moriya J, Kakeda S, Abe O et al. Gray and white matter volumetric and diffusion tensor imaging (DTI) analyses in the early stage of first-episode schizophrenia. Schizophr Res 2010;116:196203.
  • 5
    Herold R, Feldmann A, Simon M et al. Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: a voxel-based morphometric study. Acta Psychiatr Scand 2009;119:199208.
  • 6
    Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci 1995;3:8997.
  • 7
    Hulshoff-Pol HE, Schnack HG, Mandl RC et al. Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. NeuroImage 2004;21:2735.
  • 8
    Okugawa G, Tamagaki C, Agartz I. Frontal and temporal volume size of grey and white matter in patients with schizophrenia: an MRI parcellation study. Eur Arch Psychiatry Clin Neurosci 2007;257:304307.
  • 9
    Federspiel A, Begré S, Kiefer C, Schroth G, Strik WK, Dierks T. Alterations of white matter connectivity in first episode schizophrenia. Neurobiol Dis 2006;22:702709.
  • 10
    Minami T, Nobuhara K, Okugawa G et al. Diffusion tensor magnetic resonance imaging of disruption of regional white matter in schizophrenia. Neuropsychobiology 2003;47:141145.
  • 11
    Price G, Bagary MS, Cercignani M, Altmann DR, Ron MA. The corpus callosum in first episode schizophrenia: a diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 2005;76:585587.
  • 12
    Peters BD, Blaas J, de Haan L. Diffusion tensor imaging in the early phase of schizophrenia: what have we learned? J Psychiatr Res 2010;44:9931004.
  • 13
    KIM JJ, Crespo-Facorro B, Andreasen NC, O'leary DS, Magnotta V, Nopoulos P. Morphology of the lateral superior temporal gyrus in neuroleptic naive patients with schizophrenia: relationship to symptoms. Schizophr Res 2003;60:173181.
  • 14
    Bergé D, Carmona S, Rovira M, Bulbena A, Salgado P, Vilarroya O. Gray matter volume deficits and correlation with insight and negative symptoms in first-psychotic-episode subjects. Acta Psychiatr Scand 2011;123:431439.
  • 15
    Fannon D, Chitnis X, Doku V et al. Features of structural brain abnormality detected in first-episode psychosis. Am J Psychiatry 2000;157:18291834.
  • 16
    Peréz-Iglesias R, Tordesillas-Gutierréz D, McGuire PK et al. White matter integrity and cognitive impairment in first-episode psychosis. Am J Psychiatry 2010;167:451458.
  • 17
    Szeszko PR, Robinson DG, Ashtari M et al. Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology 2008;33:976984.
  • 18
    de Gracia Dominguez M, Viechtbauer W, Simons C, Van OS J, Krabbendam L. Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations. Psychol Bull 2009;135:157171.
  • 19
    Newman LM, Trivedi MA, Bendlin BB, Ries ML, Johnson SC. The relationship between gray matter morphometry and neuropsychological performance in a large Sample of cognitively healthy adults. Brain Imaging Behav 2007;1:310.
  • 20
    First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM-IV axis I disorders SCID-I: clinician version. Washington, DC: American Psychiatric Press, 1997.
  • 21
    Andreasen NC, Flaum M, Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry 1992;49:615623.
  • 22
    Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261276.
  • 23
    Emsley R, Rabinowitz J, Torreman M. RIS-INT-35 Early Psychosis Global Working Group. The factor structure for the Positive and Negative Syndrome Scale (PANSS) in recent-onset psychosis. Schizophr Res 2003;61:4757.
  • 24
    Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97113.
  • 25
    Nuechterlein KH, Green MF, Kern RS et al. The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry 2008;165:203213.
  • 26
    Ashburner J. A fast diffeomorphic image registration algorithm. NeuroImage 2007;38:95113.
  • 27
    Smith SM, Jenkinson M, Woolrich MW et al. Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 2004;23:208219.
  • 28
    Smith SM, Jenkinson M, Johansen-Berg H et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage 2006;31:14871505.
  • 29
    Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. NeuroImage 2009;44:8398.
  • 30
    Dominguez MD, Saka MC, Lieb R, Wittchen HU, van Os J. Early expression of negative/disorganized symptoms predicting psychotic experiences and subsequent clinical psychosis: a 10-year study. Am J Psychiatry 2010;167:10751082.
  • 31
    Gardner DM, Murphy AL, O'donnell H, Centorrino F, Baldessarini RJ. International consensus study of antipsychotic dosing. Am J Psychiatry 2010;167:686693.
  • 32
    Andreasen NC, Nopoulos P, Miller DD, Wassink T, Flaum M. Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biol Psychiatry 1999;46:908920.
  • 33
    Yassa MA, Stark CE. A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe. NeuroImage 2009;44:319327.
  • 34
    Nenadic I, Sauer H, Gaser C. Distinct pattern of brain structural deficits in subsyndromes of schizophrenia delineated by psychopathology. NeuroImage 2010;49:11531160.
  • 35
    Crespo-Facorro B, Kim JJ, Chemerinski E, Magnotta V, Andreasen NC, Nopoulos P. Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates. J Neuropsychiatry Clin Neurosci 2004;16:284294.
  • 36
    Pressler M, Nopoulos P, Ho BC, Andreasen NC. Insular cortex abnormalities in schizophrenia: relationship to symptoms and typical neuroleptic exposure. Biol Psychiatry 2005;57:394398.
  • 37
    Koutsouleris N, Gaser C, Jäger M et al. Structural correlates of psychopathological symptom dimensions in schizophrenia: a voxel-based morphometric study. NeuroImage 2008;39:16001612.
  • 38
    Andreasen NC, Pierson R. The role of the cerebellum in schizophrenia. Biol Psychiatry 2008;64:8188.
  • 39
    Rowland LM, Spieker EA, Francis A, Barker PB, Carpenter WT, Buchanan RW. White matter alterations in deficit schizophrenia. Neuropsychopharmacology 2009;34(1514):1522.
  • 40
    Sanfilipo M, Lafargue T, Rusinek H et al. Volumetric measure of the frontal and temporal regions in schizophrenia: relation to negative symptoms. Arch Gen Psychiatry 2000;57:471480.
  • 41
    Bertrand MC, Achim AM, Harvey PO, Sutton H, Malla AK, Lepage M. Structural neural correlates of impairments in social cognition in first episode psychosis. Soc Neurosci 2008;3:7988.
  • 42
    Haxby JV, Hoffman EA, Gobbini MI. Human neural systems for face recognition and social communication. Biol Psychiatry 2002;51:5967.
  • 43
    Behere RV, Arasappa R, Jagannathan A et al. Effect of yoga therapy on facial emotion recognition deficits, symptoms and functioning in patients with schizophrenia. Acta Psychiatr Scand 2011;123:147153.
  • 44
    Addington J, Penn D, Woods SW, Addington D, Perkins DO. Facial affect recognition in individuals at clinical risk for psychosis. Br J Psychiatry 2008;192:6768.
  • 45
    Duff K, Shoenberg MR, Scott JG, Russell LA. The relationship between executive functioning and verbal and visual learning and memory. Arch Clin Neuropsychol 2005;20:111122.
  • 46
    Andreasen NC. A unitary model of schizophrenia: Bleuler's “fragmented phrene” as schizencephaly. Arch Gen Psychiatry 1999;56:781787.