The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder
Version of Record online: 14 FEB 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Volume 128, Issue 5, pages 362–369, November 2013
How to Cite
The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder, , , , , .
- Issue online: 13 OCT 2013
- Version of Record online: 14 FEB 2013
- Manuscript Accepted: 5 DEC 2012
- Manuscript Revised: 6 OCT 2012
- Manuscript Received: 3 JUL 2012
- Sao Paulo Research Foundation
- calcium channel;
- executive function;
- CACNA1C ;
- bipolar disorder;
Calcium channels are important for converting electrical activity into biochemical events. A single nucleotide polymorphism (SNP) (rs1006737) in the CACNA1C gene has been strongly associated with increased risk for Bipolar disorder (BD) in genome-wide association studies. Recently, this same SNP has been reported to influence executive function in schizophrenia and controls, but it remains unclear whether this SNP affects behaviour, especially cognition in subjects with BD.
A total of 109 BD type I subjects and 96 controls were genotyped for CACNA1C rs1006737 and assessed with an executive function tests battery [Wechsler Adult Intelligence Scale III (WAIS-III) Letter-Number Sequence subtest (WAIS-LNS), digit span (WAISDS), trail making test (TMT), and WCST (Wisconsin Card Sorting Test)].
In patients with BD, the CACNA1C genotype Met/Met was associated with worse performance on all four executive function tests compared to Val/Val. No influence of CACNA1C was observed in the cognitive performance of healthy controls.
Our data indicate for the first time that the CACNA1C risk allele is likely associated with executive dysfunction as a trait in BD, as this association was found regardless the presence of mood symptoms. Larger studies should evaluate the potential influence of CACNA1C on other cognitive domains in BD.