The bipolar–borderline personality disorders connection in major depressive patients
Version of Record online: 4 FEB 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Volume 128, Issue 5, pages 376–383, November 2013
How to Cite
The bipolar–borderline personality disorders connection in major depressive patients, , , , , .
- Issue online: 13 OCT 2013
- Version of Record online: 4 FEB 2013
- Manuscript Accepted: 19 DEC 2012
- major depressive episode;
- bipolar disorder;
- borderline personality disorder
The study focuses on the controversial relationship between borderline personality disorder (BPD) and bipolar disorder (BD), defined according to different criteria set, in a world-wide sample of patients with a current major depressive episode (MDE).
A total of 5635 patients with an MDE were enrolled in a multinational study, designed to assess varying definition of hypo/mania and familial and clinical variables associated with bipolarity. Patients with (BPD+) and without (BPD−)comorbid BPD were compared on sociodemographic, familial and clinical characteristics.
Five hundred and thirty-two patients (9.3%) met criteria for BPD. A diagnosis of BD was more frequent in BPD+ than in BPD− using either DSM-IVTR-modified criteria or the bipolar specifier. BPD+ were younger than BPD− depressives with regard to age and age at onset. They also showed more hypomania/mania in first-degree relatives in comparison to BPD− as well as more psychiatric comorbidity, psychotic symptoms, mixed states, atypical features, seasonality of mood episodes, suicide attempts, prior mood episodes and antidepressants-induced hypo/manic switches.
In our sample, selected on the basis of the presence of a mood disorder, the BD-BPD connection is confirmed by the high prevalence of bipolarity in depressive patients with BPD and by the significant association with familial and clinical features classically considered as external validators of bipolarity.