No effect of acute tryptophan depletion on verbal declarative memory in young persons with ADHD
Article first published online: 19 FEB 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Special Issue: “Acute Tryptophan Depletion in Translational Psychiatric Research”, GUEST EDITOR Florian Daniel Zepf
Volume 128, Issue 2, pages 133–141, August 2013
How to Cite
No effect of acute tryptophan depletion on verbal declarative memory in young persons with ADHD., , , , , , .
- Issue published online: 7 JUL 2013
- Article first published online: 19 FEB 2013
- Manuscript Accepted: 3 JAN 2013
- ADHD ;
Animal experiments and studies in adults have shown that the neurotransmitter serotonin (5-HT) plays an important role in learning and memory processes. However, data on this relationship in young persons are scarce, and neurodietary research in this age group is limited compared with the extensive literature on adults. Here, we aimed to explore the effects of a diminished central nervous 5-HT synthesis, which is achieved by acute tryptophan depletion (ATD) Moja-De [1, 2], on memory function in young males with attention deficit hyperactivity disorder (ADHD).
Twenty-two male patients with ADHD (ages 9–15 years, mean 10.95 ± 1.17 years) received ATD, thus diminishing central nervous 5-HT synthesis, and a tryptophan-balanced amino acid load (BAL) in a randomized, double-blind, within-subject, crossover design study. Approximately 1.7 h after administration of ATD/BAL, verbal declarative memory was assessed using the ‘Auditory Verbal-Learning-Test’ (AVLT).
There were no significant effects of ATD administration on verbal declarative memory function.
In this study, changes in 5-HT neurotransmission were not associated with specific aspects of verbal declarative memory in young persons with ADHD. Future studies with healthy control groups that address effects of covarying attentional processes are warranted.