These authors contributed equally to this publication.
The impact of acute tryptophan depletion on attentional performance in adult patients with ADHD
Article first published online: 19 FEB 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Special Issue: “Acute Tryptophan Depletion in Translational Psychiatric Research”, GUEST EDITOR Florian Daniel Zepf
Volume 128, Issue 2, pages 124–132, August 2013
How to Cite
The impact of acute tryptophan depletion on attentional performance in adult patients with ADHD, , , , , , , , .
- Issue published online: 7 JUL 2013
- Article first published online: 19 FEB 2013
- Manuscript Accepted: 3 JAN 2013
- ADHD ;
- acute tryptophan depletion;
To date, the impact of the neurotransmitter serotonin (5-HT) on different neuropsychological functions in adults with attention deficit hyperactivity disorder (ADHD) is underinvestigated. We aimed to examine the effects of acute tryptophan depletion (ATD) and the resulting reduction in central nervous 5-HT synthesis on target/non-target discrimination ability and sustained attention in adults with ADHD using an AX-Continuous Performance Test (AX-CPT).
Twenty male patients with ADHD (age: M = 30.25 SD = 9.37) and twenty male healthy controls (age: M = 27.90 SD = 6.01) received ATD on one day and a tryptophan-balanced control condition (BAL) on another day in a double-blind within-subject crossover design. A continuous performance test (AX-CPT) with three conditions (AX, AY, and BX) was administered on both days under depleted and sham-depleted conditions.
In patients omissions increased after ATD when compared with BAL. Patient's reaction time decreased after ATD when compared with BAL, which was contrasted by opposite effects in controls. Patients showed fewer correct responses (AX condition) and showed a higher rate of errors (condition AXE) independent of ATD or BAL intake.
The present preliminary results are indicative of the contribution of serotonergic neurotransmission to attentional processes in adults with ADHD.