Both authors contributed equally to this work.
Resting-state connectivity deficits associated with impaired inhibitory control in non-treatment-seeking adolescents with psychotic symptoms
Article first published online: 26 APR 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Volume 129, Issue 2, pages 134–142, February 2014
How to Cite
Resting-state connectivity deficits associated with impaired inhibitory control in non-treatment-seeking adolescents with psychotic symptoms., , , , , , , , , , , , .
- Issue published online: 7 JAN 2014
- Article first published online: 26 APR 2013
- Manuscript Accepted: 27 MAR 2013
- Clinician Scientist Award. Grant Number: CSA/2004/1
- Health Research Board (Ireland)
- Health Research Award. Grant Number: HRA PHS/2012/28
- Health Research Board Ireland
- NARSAD Essel Independent Investigator
- European Community's Seventh Framework Programme. Grant Number: HEALTH-F2-2010-241909
- European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)
- psychotic symptoms;
- functional magnetic resonance imaging;
- intrinsic functional connectivity
Psychotic symptoms are common in the population and index risk for a range of severe psychopathological outcomes. We wished to investigate functional connectivity in a community sample of adolescents who reported psychotic symptoms (the extended psychosis phenotype).
This study investigated intrinsic functional connectivity (iFC) during resting-state functional magnetic resonance imaging (fMRI; rs-fMRI). Following screening in schools, 11 non-treatment seeking, youth with psychotic symptoms (aged 11–13) and 14 community controls participated in the study. Seed regions of interest comprised brain regions previously shown to exhibit aberrant activation during inhibitory control in adolescents with psychotic symptoms.
Relative to controls, adolescents with psychotic symptoms exhibited reduced iFC between regions supporting inhibitory control. Specifically, they showed weaker iFC between the right inferior frontal gyrus (IFG) and the cingulate, IFG and the striatum, anterior cingulate and claustrum, and precuneus and supramarginal gyrus. Conversely, the psychotic symptoms group exhibited stronger iFC between the superior frontal gyrus and claustrum and IFG and lingual gyrus.
The present findings are the first to reveal aberrant functional connectivity in resting-state networks in a community sample of adolescents with psychotic symptoms and suggest that disruption in integration between distributed neural networks (particularly between prefrontal, cingulate and striatal brain regions) may be a key neurobiological feature of the extended psychosis phenotype.