The neurobiological correlates of childhood adversity and implications for treatment
Article first published online: 10 MAY 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Volume 128, Issue 6, pages 434–447, December 2013
How to Cite
The neurobiological correlates of childhood adversity and implications for treatment., , , , .
- Issue published online: 11 NOV 2013
- Article first published online: 10 MAY 2013
- Manuscript Accepted: 3 APR 2013
- National Institute of Mental Health. Grant Numbers: R01 MH083704 ART, R21 MH091508 ART, R01 MH068767-01 LLC
- early-life stress;
- childhood abuse;
This article provides an overview of research on the neurobiological correlates of childhood adversity and a selective review of treatment implications.
Findings from a broad array of human and animal studies of early adversity were reviewed.
Topics reviewed include neuroendocrine, neurotrophic, neuroimaging, and cognitive effects of adversity, as well as genetic and epigenetic influences. Effects of early-life stress on treatment outcome are considered, and development of treatments designed to address the neurobiological abnormalities is discussed.
Early adversity is associated with abnormalities of several neurobiological systems that are implicated in the development of psychopathology and other medical conditions. Early-life stress negatively impacts treatment outcome, and individuals may require treatments that are specific to this condition.