Hippocampal volume in relation to clinical and cognitive outcome after electroconvulsive therapy in depression
Article first published online: 8 JUN 2013
© 2013 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
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Acta Psychiatrica Scandinavica
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Hippocampal volume in relation to clinical and cognitive outcome after electroconvulsive therapy in depression., , , .
- Article first published online: 8 JUN 2013
- Manuscript Accepted: 22 APR 2013
- Governmental Funding of clinical research
- the Crafoord Foundation
- Ellen and Henrik Sjöbring's Foundation
- the Söderström-Königska Foundation
- Thure Carlsson's Foundation
- the OM Persson Foundation
- The Alzheimer Foundation
- Knut and Alice Wallenberg's Foundation. Grant Number: 1998.0182
- Greta and Johan Kock's Foundation
- magnetic resonance imaging;
- electroconvulsive therapy;
In a previous magnetic resonance imaging (MRI) study, we found a significant increase in hippocampal volume immediately after electroconvulsive therapy (ECT) in patients with depression. The aim of this study was to evaluate hippocampal volume up to 1 year after ECT and investigate its possible relation to clinical and cognitive outcome.
Clinical and cognitive outcome in 12 in-patients with depression receiving antidepressive pharmacological treatment referred for ECT were investigated with the Montgomery–Asberg Depression Rating Scale (MADRS) and a broad neuropsychological test battery within 1 week before and after ECT. The assessments were repeated 6 and 12 months after baseline in 10 and seven of these patients, respectively. Hippocampal volumes were measured on all four occasions with 3 Tesla MRI.
Hippocampal volume returned to baseline during the follow-up period of 6 months. Neither the significant antidepressant effect nor the significant transient decrease in executive and verbal episodic memory tests after ECT could be related to changes in hippocampal volume. No persistent cognitive side effects were observed 1 year after ECT.
The immediate increase in hippocampal volume after ECT is reversible and is not related to clinical or cognitive outcome.