Pericardial, intra-abdominal, and subcutaneous adipose tissue in patients with major depressive disorder
Article first published online: 17 JAN 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Acta Psychiatrica Scandinavica
Volume 130, Issue 2, pages 137–143, August 2014
How to Cite
Pericardial, intra-abdominal, and subcutaneous adipose tissue in patients with major depressive disorder., , , , , , , , , , .
- Issue published online: 8 JUL 2014
- Article first published online: 17 JAN 2014
- Manuscript Accepted: 3 DEC 2013
- cardio-vascular diseases;
- diabetes mellitus
Major depressive disorder (MDD) is associated with an increased risk for developing coronary artery disease (CAD). Recently, pericardial adipose tissue, a metabolically active visceral fat depot surrounding the heart, has been implicated in the pathogenesis of CAD. Therefore, we investigated pericardial adipose tissue volumes in patients with MDD and compared them to healthy comparison subjects.
In this case-control study at a university medical center, 50 male and female in-patients with MDD and 25 healthy men and women were examined. The main outcome measures were the volumes of pericardial adipose tissue, intra-abdominal adipose tissue (IaAT) and subcutaneous adipose tissue (ScAT) which were measured using magnetic resonance imaging.
The pericardial adipose tissue volumes were greater in men and women with MDD compared with the healthy comparison group following adjustments for the effects of age, weight, height, and physical activity.
This study expands our knowledge about the alterations in body composition that occur in patients with MDD. The findings are highly relevant for understanding the comorbidity between heart disease and depressive disorders.