Get access

Correlation of plasma brain-derived neurotrophic factor and metabolic profiles in drug-naïve patients with bipolar II disorder after a twelve-week pharmacological intervention

Authors

  • S.-Y. Lee,

    1. Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    2. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Search for more papers by this author
  • S.-L. Chen,

    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    2. Department of Neurology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Search for more papers by this author
  • Y.-H. Chang,

    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    2. Institute of Allied Health Sciences, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
    Search for more papers by this author
  • P.-S. Chen,

    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Search for more papers by this author
  • S.-Y. Huang,

    1. Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Search for more papers by this author
  • N.-S. Tzeng,

    1. Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Search for more papers by this author
  • C.-L. Wang,

    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Search for more papers by this author
  • L.-J. Wang,

    1. Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Search for more papers by this author
  • I.-H. Lee,

    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Search for more papers by this author
  • T.-Y. Wang,

    1. Department of Psychiatry, Department of Health, Tainan Hospital, Tainan, Taiwan
    Search for more papers by this author
  • K.-C. Chen,

    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    2. Department of Psychiatry, National Cheng Kung University Hospital, Yunlin, Taiwan
    Search for more papers by this author
  • Y.-K. Yang,

    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    2. Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
    Search for more papers by this author
  • J.-S. Hong,

    1. Laboratory of Toxicology and Pharmacology, NIH/NIEHS, Research Triangle Park, Durham, NC, USA
    Search for more papers by this author
  • R.-B. Lu

    Corresponding author
    1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    2. Department of Neurology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    3. Department of Psychiatry, National Cheng Kung University Hospital, Yunlin, Taiwan
    4. Institute of Behavioral Medicine, Tainan, Taiwan
    5. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan
    • Ru-Band Lu, Institute of Behavioral Medicine, Department of Psychiatry, Addiction Center, College of Medicine and Hospital, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, Taiwan.

      E-mail: rblu@mail.ncku.edu.tw

    Search for more papers by this author

Abstract

Objective

Brain-derived neurotrophic factor (BDNF) is thought to be involved in the pathophysiology of bipolar disorder (BD) and metabolic syndrome. We investigated the correlation between plasma BDNF with mood symptoms and metabolic indices in patients with BD-II over a 12-week pharmacological intervention.

Method

Drug-naïve patients with BD-II (n = 117) were recruited. Metabolic profiles [cholesterol, triglyceride, HbA1C, fasting serum glucose, body mass index (BMI)] and plasma BDNF wtrun "tblautotrun "tblsctrun "tbl_contere measured at baseline and 2, 8, and 12 weeks after beginning medication. To adjust within-subject dependence over repeated assessments, multiple linear regressions with generalized estimating equation methods were used.

Results

Seventy-six (65.0%) patients completed the intervention. Plasma BDNF levels were significantly associated with BMI (P = 9.6E-5), low-density lipoprotein (P = 0.034) and total (= 0.001) cholesterol, but not with the Hamilton Depression Rating Scale-17 and Young Mania Rating Scale scores over the 12-week treatment.

Conclusion

We found initial evidence of a positive correlation between plasma BDNF levels and BMI, low-density lipoprotein and total cholesterol in drug-naïve patients with BD-II. The specific function of BDNF in regulating and maintaining peripheral metabolic health requires additional investigation.

Get access to the full text of this article

Ancillary