Editor: Karina Acevedo-Whitehouse
Low MHC variation in the polar bear: implications in the face of Arctic warming?
Article first published online: 2 MAY 2013
© 2013 The Zoological Society of London
Volume 16, Issue 6, pages 671–683, December 2013
How to Cite
Weber, D. S., Van Coeverden De Groot, P. J., Peacock, E., Schrenzel, M. D., Perez, D. A., Thomas, S., Shelton, J. M., Else, C. K., Darby, L. L., Acosta, L., Harris, C., Youngblood, J., Boag, P. and Desalle, R. (2013), Low MHC variation in the polar bear: implications in the face of Arctic warming?. Animal Conservation, 16: 671–683. doi: 10.1111/acv.12045
- Issue published online: 26 NOV 2013
- Article first published online: 2 MAY 2013
- Manuscript Accepted: 14 MAR 2013
- Manuscript Received: 20 FEB 2012
- Nunavut Wildlife Management Board
- Nunavut Tuungavik Inc.
- National Science and Engineering Council, Canada
- polar bear;
- climate change;
Animals in the Arctic have low pathogen diversity but with rapid climate warming, this is expected to change. One insidious consequence of climate change is exposure of Arctic species to new pathogens derived from more southern species expanding their range northward. To assess potential vulnerability of polar bears to disease exposure, we examined genetic variation in major histocompatibility complex (MHC) loci (part of immune system) in Canadian polar bears and found low genetic diversity, consistent with long-standing exposure to low pathogen/parasite loads. All polar bears surveyed showed maximum linkage disequilibrium between DRB/DQB loci and 12% of individuals had a duplicated DQB gene haplotype. These results may reflect balancing selection at these loci, a response to an earlier immune-challenge and/or be artifacts of polar bear-brown bear divergence. Consistent with the latter, we found one DQA allele in polar bears that was also a brown bear DQA allele. The reported low MHC diversity and high linkage disequilibrium may have serious implications for polar bear resistance to new pathogens, which would be maladaptive to species in an environment undergoing rapid climate change, such as the Arctic.