BRIEF REPORT: PRECLINICAL STUDY
Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats
Article first published online: 12 DEC 2012
Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Volume 19, Issue 3, pages 338–342, May 2014
How to Cite
Bossert, J. M. and Stern, A. L. (2014), Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats. Addiction Biology, 19: 338–342. doi: 10.1111/adb.12015
- Issue published online: 17 APR 2014
- Article first published online: 12 DEC 2012
- Intramural Research Program of the National Institute on Drug Abuse
- Conditioned cues;
- drug environment;
- heroin self-administration;
- muscimol + baclofen;
In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma-aminobutyric acid agonists muscimol + baclofen decreased context-induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context-induced relapse across drug classes.