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Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats

Authors

  • Jennifer M. Bossert,

    Corresponding author
    1. Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD, USA
    • Correspondence to: Jennifer M. Bossert, Behavioural Neuroscience, IRP-NIDA, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA. E-mail: jbossert@intra.nida.nih.gov

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  • Anna L. Stern

    1. Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD, USA
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Abstract

In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma-aminobutyric acid agonists muscimol + baclofen decreased context-induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context-induced relapse across drug classes.

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