Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395
Version of Record online: 30 JAN 2013
© 2013 The Authors, Addiction Biology © 2013 Society for the Study of Addiction
Volume 19, Issue 4, pages 606–611, July 2014
How to Cite
Simms, J. A., Nielsen, C. K., Li, R. and Bartlett, S. E. (2014), Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395. Addiction Biology, 19: 606–611. doi: 10.1111/adb.12024
- Issue online: 9 JUL 2014
- Version of Record online: 30 JAN 2013
- State of California for Medical Research through UCSF
- Department of Defense. Grant Number: W81XWH-10-1-0247
Figure S1 CP-376395 significantly reduced ethanol consumption (g/kg) in animals trained on the intermittent access (IAE) schedule 6 hours after the onset of the drinking session but had no effect in the continuous access (CA) group (a). Similarly, CP-376395 significantly reduced ethanol preference in the IAE animals 6 hours after the onset of the drinking session but had no effect in the CA group (b). CP-376395 significantly increased water intake in the IAE animals 6 hours after the onset of the drinking session but had no effect in the CA group. The values are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, compared to IAE vehicle treatment, + P < 0.05, ++ P < 0.01, compared to IAE baseline, ## P < 0.01, ### P < 0.001 comparing IAE baseline to CA baseline, ■ P < 0.05, ■■ P < 0.01, comparing IAE vehicle to CA vehicle, ○ P < 0.05, ○○ P < 0.01, comparing IAE 5 mg/kg to CA 5 mg/kg. Two-way ANOVA with repeated measures, Newman-Keuls post hoc test.
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