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Figure S1 CP-376395 significantly reduced ethanol consumption (g/kg) in animals trained on the intermittent access (IAE) schedule 6 hours after the onset of the drinking session but had no effect in the continuous access (CA) group (a). Similarly, CP-376395 significantly reduced ethanol preference in the IAE animals 6 hours after the onset of the drinking session but had no effect in the CA group (b). CP-376395 significantly increased water intake in the IAE animals 6 hours after the onset of the drinking session but had no effect in the CA group. The values are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, compared to IAE vehicle treatment, + P < 0.05, ++ P < 0.01, compared to IAE baseline, ## P < 0.01, ### P < 0.001 comparing IAE baseline to CA baseline, ■ P < 0.05, ■■ P < 0.01, comparing IAE vehicle to CA vehicle, ○ P < 0.05, ○○ P < 0.01, comparing IAE 5 mg/kg to CA 5 mg/kg. Two-way ANOVA with repeated measures, Newman-Keuls post hoc test.

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