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Figure S1 Saccharin and quinine intake by MeCP2308/Y and wild-type (WT) mice. The MeCP2308/Y mutation did not impact taste function as indicated by equal consumption of saccharin and quinine solutions as WT mice. (a) Intake of 0.033 and 0.066% solutions of saccharin and (b) quinine solutions of 0.015 and 0.06 mM. (c) Preference for saccharin and (d) quinine at the same concentration in A, B. Levels of intake and preference of saccharin and quinine are in keeping with previous results with C57BL/6J mice (Lim et al. 2012)

Figure S2 Water intake and alcohol preference in the course of the chronic intermittent ethanol exposure experiment shown in Fig. 4b. (a) Overall, water intake was higher in MeCP2308/Y mice compared to wild-type (WT) mice (significant main effect of genotype: F1,48 = 6.465, P = 0.0217). (b) An increase of total fluid intake in WT mice was observed over the three vapor bouts (significant main effect of genotype: F1,48 = 15.39, P = 0.001; session: F3,48 = 3.76, P = 0.017; by RM two-way analysis of variance). Bonferroni post hoc tests confirmed a significant increased drinking of WT mice (†P < 0.05) versus baseline (Pre) and versus MeCP2308/Y (**P < 0.01). (c) Preference for alcohol was higher in WT compared to MeCP2308/Y mice (significant main effect of genotype: F1,48 = 7.437, P = 0.0149; with a significant difference (P < 0.05) between WT and MeCP2308/Y after the second and third postvapor session)

Table S1 GSEA results

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