Functional alteration in frontolimbic systems relevant to moral judgment in cocaine-dependent subjects (pages 272–281)
Antonio Verdejo-Garcia, Oren Contreras-Rodríguez, Francina Fonseca, Aida Cuenca, Carles Soriano-Mas, Joan Rodriguez, Ricardo Pardo-Lozano, Laura Blanco-Hinojo, Susana de Sola Llopis, Magí Farré, Marta Torrens, Jesús Pujol and Rafael de la Torre
Article first published online: 11 JUL 2012 | DOI: 10.1111/j.1369-1600.2012.00472.x
During the functional resonance imaging moral decision-making task (e.g., “would you throw a dying person into the sea to float a lifeboat full of survivors?”), cocaine dependent users displayed significantly reduced signal in brain regions involved in generating and instantiating emotions (i.e., insula, anterior cingulate cortex and brainstem periacqueductal gray). We reason that cocaine dependent users exhibit blunted responsiveness of the brain network that normally anticipates potentially aversive emotional consequences of complex social decisions.