Neural activation during processing of aversive faces predicts treatment outcome in alcoholism (pages 439–451)
Katrin Charlet, Florian Schlagenhauf, Anne Richter, Karina Naundorf, Lina Dornhof, Christopher E. J. Weinfurtner, Friederike König, Bernadeta Walaszek, Florian Schubert, Christian A. Müller, Stefan Gutwinski, Annette Seissinger, Lioba Schmitz, Henrik Walter, Anne Beck, Jürgen Gallinat, Falk Kiefer and Andreas Heinz
Version of Record online: 7 MAR 2013 | DOI: 10.1111/adb.12045
While neuropsychological studies reported decoding deficits of emotional faces in alcohol-dependent patients, imaging studies revealed reduced prefrontal/limbic activation during emotional face processing. We investigated whether this reduced neuronal activation is mediated by brain atrophy and whether it interacts with treatment outcome. We combined structural and functional brain analyses (Hariri faces-task) on data sets of 33 detoxified alcoholics and 33 matched controls. Low atrophy and high activation of rostral ACC elicited by affective faces appear to be resilience factors predicting better treatment outcome.