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Figure S1 The association between rs588775 with (a) cotinine levels, (b) urinary total nicotine equivalents (TNE), (c) urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and (d) urinary 1-hydroxypryrene. IQR: interquartile range

Figure S2 The association (by dominate models) between rs578776 with (a) cotinine levels, (b) urinary total nicotine equivalents (TNE), (c) urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and (d) urinary 1-hydroxypryrene. IQR: interquartile range. The P-values were obtained from dominate models

Figure S3 The combined impact of rs16969968 in CHRNA5-A3-B4 and CYP2A6 activity on urinary urinary total nicotine equivalents (TNE) levels. The P-values were obtained by non-parametric comparisons (Mann–Whitney U- or Kruskal–Wallis tests)

Table S1 A list of the single nucleotide polymorphism (SNP) markers selection.

Table S2 The association between CHRNA5-A3-B4 single nucleotide polymorphisms (SNPs) and cigarettes per day (CPD), Fagerström Test for Nicotine Dependence (FTDN), cotinine (COT), urinary total nicotine equivalents (TNE), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and body mass index (BMI) (additive models).

Table S3 The association between rs2869550 and body mass index (BMI) (additive model).

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